Miscellaneous Antidepressants Flashcards
Venlafaxine uses?
1) Depression
2) Anxiety
3) ADHD
Do NOT use in hypertensive pts?
Venlafaxine
Duloxetine uses?
1) Depression
2) Neuropathic pain or fibromyalgia
Causes liver AEs in pts with liver dz or heavy alcohol use?
Duloxetine
Bupropion uses?
1) Depression
2) Smoking cessation aid
3) Adult ADHD
Bupropion AEs?
Seizures, psychosis at high doses, anxiety
Trazodone uses?
1) Refractory depression
2) MDD with anxiety
3) Insomnia
T/F Trazodone causes sexual AEs.
False, do not affect sex or sleep
AEs of trazodone?
Nausea, dizziness, orthostatic hypotension, cardiac arrhythmias, sedation and priapism
Black Box Warning for rare but serious liver failure?
Nefazodone
Mirtazapine uses?
Refractory depression (esp those who need to gain weight and need sleep)
Mirtazapine AEs?
Sedation, weight gain, dizziness, somnolence, tremor, dry mouth, constipation, rare agranulocytosis (no sexual)
Amitriptyline uses?
1) Chronic pain
2) Migraines
3) Insomnia
Impipramine uses?
1) Enuresis
2) Panic disorder
Clomipramine uses?
OCD (due to being serotonin specific)
Doxepin uses?
1) Chronic pain
2) Sleep aid
Nortriptyline uses?
Chronic pain
TCA OD tx?
IV Na bicarbonate
Metabolite of antipsychotc loxapine?
Amoxapine
May cause EPS?
Amoxapine
AEs of maprotiline?
Seizure, arrhythmia, fatality in OD
AEs of TCAs?
1) Antihistamine
2) Antiadrenergic = wide QRS, QT, and PRi
3) Antimuscarinic
4) Weight gain, seizures
5) Serotonergic effects = erectile/ejaculatory dysfunction, anorgasmia in femailes
MAO-A?
1) Serotonin
2) Dopamine
3) Tyramine
MAO-B?
1) NE/epinephrine
2) Dopamine
3) Tyramine
Serotonin syndrome tx?
1) D/C drug
2) CCB (oral nifedipine)
3) Maybe chlorpromazine or phentolamine
Most common AE of MAOIs?
Orthostatic hypotension
