Miscellaneous Antidepressants

Question 1

Venlafaxine uses?

Answer 1

1) Depression
2) Anxiety
3) ADHD

Question 2

Do NOT use in hypertensive pts?

Answer 2

Venlafaxine

Question 3

Duloxetine uses?

Answer 3

1) Depression

2) Neuropathic pain or fibromyalgia

Question 4

Causes liver AEs in pts with liver dz or heavy alcohol use?

Answer 4

Duloxetine

Question 5

Bupropion uses?

Answer 5

1) Depression
2) Smoking cessation aid
3) Adult ADHD

Question 6

Bupropion AEs?

Answer 6

Seizures, psychosis at high doses, anxiety

Question 7

Trazodone uses?

Answer 7

1) Refractory depression
2) MDD with anxiety
3) Insomnia

Question 8

T/F Trazodone causes sexual AEs.

Answer 8

False, do not affect sex or sleep

Question 9

AEs of trazodone?

Answer 9

Nausea, dizziness, orthostatic hypotension, cardiac arrhythmias, sedation and priapism

Question 10

Black Box Warning for rare but serious liver failure?

Answer 10

Nefazodone

Question 11

Mirtazapine uses?

Answer 11

Refractory depression (esp those who need to gain weight and need sleep)

Question 12

Mirtazapine AEs?

Answer 12

Sedation, weight gain, dizziness, somnolence, tremor, dry mouth, constipation, rare agranulocytosis (no sexual)

Question 13

Amitriptyline uses?

Answer 13

1) Chronic pain
2) Migraines
3) Insomnia

Question 14

Impipramine uses?

Answer 14

1) Enuresis

2) Panic disorder

Question 15

Clomipramine uses?

Answer 15

OCD (due to being serotonin specific)

Question 16

Doxepin uses?

Answer 16

1) Chronic pain

2) Sleep aid

Question 17

Nortriptyline uses?

Answer 17

Chronic pain

Question 18

TCA OD tx?

Answer 18

IV Na bicarbonate

Question 19

Metabolite of antipsychotc loxapine?

Answer 19

Amoxapine

Question 20

May cause EPS?

Answer 20

Amoxapine

Question 21

AEs of maprotiline?

Answer 21

Seizure, arrhythmia, fatality in OD

Question 22

AEs of TCAs?

Answer 22

1) Antihistamine
2) Antiadrenergic = wide QRS, QT, and PRi
3) Antimuscarinic
4) Weight gain, seizures
5) Serotonergic effects = erectile/ejaculatory dysfunction, anorgasmia in femailes

Question 23

MAO-A?

Answer 23

1) Serotonin
2) Dopamine
3) Tyramine

Question 24

MAO-B?

Answer 24

1) NE/epinephrine
2) Dopamine
3) Tyramine

Question 25

Serotonin syndrome tx?

Answer 25

1) D/C drug
2) CCB (oral nifedipine)
3) Maybe chlorpromazine or phentolamine

Question 26

Most common AE of MAOIs?

Answer 26

Orthostatic hypotension