Sporozoa Flashcards
Cause of malaria
Plasmodium
IH & DH of Plasmodium
IH: sporozoites
DH: gameotcyte
Symptoms and pathology of plasmodium
- Recurrent chills and fever
- Anemia, splenomegaly, joint pain
- Cerebral malaria: RBC, organisms a d pigment block brain vessels
Blackwater fever: intravascular hemolysis + hemoglobinuria
Resistant to malaria
G6PD Deficiency
Fy null
Sickle cell disease
Dormant stage
Found in liver
Once activated, releases merozoites
Responsible for relapse
Hypmozoites
Mixed infection in plasmodium
P. Vivax and P. Falciparum
Lab diagnosis of plasmodium
- Examination of blood film (thick and thin blood film)
- QBC: quantitative buffy coat (fluorochrome: acridinenirande)
- Immunotests(optimal assay: detects pLDH= malarial organism, malaquick test)
Prevalent worlwide
Single large ring succeeded by amoeboid form in pale large red cell
Plasmodium vivax
Schuffner’s dots
P. Vivax
Single large compact ring or band forms
Invades old RBCs
Schizont arranged around central pigment
P. Malariae
Ziemanns dots
P. Malariae
Prevalent in the philippines
Formation /double chromatin dots
Multiple parasitization of red cell
Infects all age of red cells
P. Falciparum
Maurer’s dots (Stephen Chrostopher/Cuneiform)
P. Falciparum
Single compact ring
Infected RBCs: serrated/fimbriated
Plasmodium ovale
Schuffner’s dots/ James dots