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Basic Neuroscience > SPMM > Flashcards

SPMM Flashcards

1
Q

Empathy

A

Supramarginal gyrus

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2
Q

Angular gyrus (L)

A

Gerstmann’s

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3
Q

Striatum

A

Dorsal striatum = caudate nucleus + lentiform nucleus (putamen + globus pallidus)

Ventral striatum = nucleus accumbens and olfactory tubercle

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4
Q

Molecular biology tests

A

Southwestern - DNA binding proteins

Northwestern - hybrid method for detecting interactions between RNA and proteins

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5
Q

Locked in syndrome

A

Pons

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6
Q

Enzymes involved in making amyloid plaques

A

Alpha secretase - protective
Beta and gamma secretase (AB derived from APP by)

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7
Q

Parkinson’s

A

Increased sensitivity to dopamine in substantia nigra

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8
Q

Secondary messengers

A

Calcium
cAMP
cGMP
Inositol trisphosphate
Diacylglycerol

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9
Q

Prion diseases

A

Cerebellum

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10
Q

Tau

A

Chr 17

Stabilises microtubules

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11
Q

TOL

A

Executive function - planning

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12
Q

Endocannibinoid receptors

A

Metabotropic

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13
Q

Rate limiting step in alcohol metabolism

A

Alcohol dehydrogenase

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14
Q

Silver staining, spherical shaped aggregations

A

Tau

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15
Q

Identify tract specific lesion

A

DTI

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16
Q

IGF-1

A

Primarily produced by the liver

Also called somatomedin C

17
Q

Area not involved in wakefulness

A

Cerebellum

18
Q

Epigenetic mechanisms

A

DNA acetylation
DNA methylation
Histone phosphorylation
Histone methylation
Imprinting
Alternate splicing

19
Q

Schizophrenia

A

Decreased prefrontal and hippocampal activation

20
Q

Prefrontal cortex

A

15%

21
Q

Anomia

A

Arcuate fasciculus

22
Q

Dopamine receptors

A

D1 receptors most abundant in the brain

23
Q

Ideational apraxia

A

Cannot follow instructions / plan movements

24
Q

Ideomotor apraxia

A

Struggles to imitate or mime movements

25
Q

Hummingbird sign

A

PSP

26
Q

Tetrabenazine

A

Inhibits vesicular monoamine transporter 2

27
Q

Most dopamine action

A

Duloxetine

28
Q

Donepezil breakdown

A

CYP450 2D6 and 3A4

29
Q

Postural hypotension antidepressants

A

Mirtazapine
Trazodone

30
Q

T wave flattening

A

Hypokalaemia

31
Q

Antidepressant with an active metabolite

A

Sertraline

32
Q

DBS

A

PD - subthalamic nucleus, internal globus pallidus

Treatment resistant OCD - ventral internal capsule, STN

Tourette’s - ventromedial thalamus

Treatment resistant depression - subcallosal cingulate

33
Q

Mouse models

A

BPAD - circadian rhythm disruption, BDNF haploinsufficient mice, ERK1 knockout

Depressive disorder - olfactory bulbectomy, social defeat, maternal deprivation, chronic restraint

Basic Neuroscience (9 decks)

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