SPMM

Question 1

Empathy

Answer 1

Supramarginal gyrus

Question 2

Angular gyrus (L)

Answer 2

Gerstmann’s

Question 3

Striatum

Answer 3

Dorsal striatum = caudate nucleus + lentiform nucleus (putamen + globus pallidus)

Ventral striatum = nucleus accumbens and olfactory tubercle

Question 4

Molecular biology tests

Answer 4

Southwestern - DNA binding proteins

Northwestern - hybrid method for detecting interactions between RNA and proteins

Question 5

Locked in syndrome

Answer 5

Pons

Question 6

Enzymes involved in making amyloid plaques

Answer 6

Alpha secretase - protective
Beta and gamma secretase (AB derived from APP by)

Question 7

Parkinson’s

Answer 7

Increased sensitivity to dopamine in substantia nigra

Question 8

Secondary messengers

Answer 8

Calcium
cAMP
cGMP
Inositol trisphosphate
Diacylglycerol

Question 9

Prion diseases

Answer 9

Cerebellum

Question 10

Tau

Answer 10

Chr 17

Stabilises microtubules

Question 11

TOL

Answer 11

Executive function - planning

Question 12

Endocannibinoid receptors

Answer 12

Metabotropic

Question 13

Rate limiting step in alcohol metabolism

Answer 13

Alcohol dehydrogenase

Question 14

Silver staining, spherical shaped aggregations

Answer 14

Tau

Question 15

Identify tract specific lesion

Answer 15

DTI

Question 16

IGF-1

Answer 16

Primarily produced by the liver

Also called somatomedin C

Question 17

Area not involved in wakefulness

Answer 17

Cerebellum

Question 18

Epigenetic mechanisms

Answer 18

DNA acetylation
DNA methylation
Histone phosphorylation
Histone methylation
Imprinting
Alternate splicing

Question 19

Schizophrenia

Answer 19

Decreased prefrontal and hippocampal activation

Question 20

Prefrontal cortex

Answer 20

15%

Question 21

Anomia

Answer 21

Arcuate fasciculus

Question 22

Dopamine receptors

Answer 22

D1 receptors most abundant in the brain

Question 23

Ideational apraxia

Answer 23

Cannot follow instructions / plan movements

Question 24

Ideomotor apraxia

Answer 24

Struggles to imitate or mime movements

Question 25

Hummingbird sign

Answer 25

PSP

Question 26

Tetrabenazine

Answer 26

Inhibits vesicular monoamine transporter 2

Question 27

Most dopamine action

Answer 27

Duloxetine

Question 28

Donepezil breakdown

Answer 28

CYP450 2D6 and 3A4

Question 29

Postural hypotension antidepressants

Answer 29

Mirtazapine Trazodone

Question 30

T wave flattening

Answer 30

Hypokalaemia

Question 31

Antidepressant with an active metabolite

Answer 31

Sertraline

Question 32

DBS

Answer 32

PD - subthalamic nucleus, internal globus pallidus Treatment resistant OCD - ventral internal capsule, STN Tourette's - ventromedial thalamus Treatment resistant depression - subcallosal cingulate

Question 33

Mouse models

Answer 33

BPAD - circadian rhythm disruption, BDNF haploinsufficient mice, ERK1 knockout Depressive disorder - olfactory bulbectomy, social defeat, maternal deprivation, chronic restraint