Pathology findings Flashcards
Papp-Lantos bodies
MSA
Glial cytoplasmic inclusion bodies visible in the CNS
Pick bodies
FTD
Large, dark staining aggregates of proteins in neurological tissue
Lewy bodies
PD and LBD
Round, concentrically laminated, pale eosinophilic cytoplasmic inclusions (aggregates of alpha synuclein)
Asteroid bodies
Sarcoidosis and berylliosis
Acidophillic, stellate inclusions in giant cells
Barr bodies
Stains of X chromosomes
Inactivated X chromosome - dark staining mass in contact with the nuclear membrane
Mallory bodies
Found in alcoholic hepatitis, alcoholic cirrhosis, Wilson’s disease, primary biliary cirrhosis
Alcoholic hyalin-eosinophilic intracytoplasmic inclusions in hepatocytes: intermediate filaments, predominantly prekeratin
Schaumann bodies
Sarcoidosis and berylliosis
Concentrically laminated inclusions in giant cells
Zebra bodies
Niemann-Pick disease, Tay-Sachs disease, any mucopolysaccharidoses
Palisaded lamellated membranous cytoplasmic bodies seen in macrophages
LE bodies (haematoxylin bodies)
Lupus
Nuclei of damaged cells with bound ANA which become homogenous and loose chromatin pattern
Verocay bodies
Schwannoma (Neurilemoma)
Palisades of nuclei at the end of a fibrillar bundle
Hirano bodies
Normal ageing but more numerous in AD
Eosinophilic, football shaped inclusions seen in neurons of the brain
Neurofibrillary tangles
AD
Microtubule- associated proteins and neurofilaments
Kayser-Fleischer rings
Rings of discolouration on cornea
Kuru plaques
Kuru and Gerstmann-Straussler syndrome, sometimes CJD
Composed partly of a host-encoded prion protein
