Spleen Flashcards
1
Q
Etiology of ITP?
A
IgG antibodies are made that coat platelets. Red pulp phagocytes destroy platelets
2
Q
ITP patient presents with severe bleeding. How do you treat?
A
IgG infusion
3
Q
What is the elective surgical treatment for ITP? What is the success rate?
A
Splenectomy
70% success rate
4
Q
Purpura, acute fever, weakness, confusion, headache, AKI
A
Thrombotic thrombocytopenia purpura (TTP)
5
Q
TTP pathophysiology
A
Autoantibody inhibits ADAMTS13 enzyme so vWF multimers are not cleaved into smaller units resulting in increased platelet adhesion
6
Q
TTP treatment
A
Plasmapheresis
7
Q
Vaccines to prevent OPSI
A
Strep. pneumonia
H. influenza
Meningococcus
8
Q
Most common organism responsible for OPSI?
A
Strep pneumonia
