spine - essay plan Flashcards
INTRO
- function
- structure
INTRO
- function = allows movement, prevents damage so spinal cord, comprises axial skeleton
- structure = segmental, regional variations, different curvatures
DEVELOPMENT OF VERTEBRAE
- what is the neural tube and where is it in the trilaminar disc?
- neural tube is the precursor of the CNS
- it lies above the signalling notochord in the midline of the mesoderm
DEVELOPMENT OF VERTEBRAE
- what occurs in the paraxial mesoderm?
- paraxial mesoderm forms somites into a segmental arrangement
DEVELOPMENT OF VERTEBRAE
- what do the somites do?
- somites differentiate into
1. dermomyotome
2. sclerotome
DEVELOPMENT OF VERTEBRAE
what part of the somite forms the scelerotome?
ventromedial (front and middle) part of somite forms the sclerotome by epithelial to mesenchymal transition
DEVELOPMENT OF VERTEBRAE
how does the precursor the vertebral column form?
- sclerotome cells surround the notochord and neural tube
2. other parts of somite form myotome for the segmental muscles
DEVELOPMENT OF VERTEBRAE
how does sclerotome divide
after forming the precursor of the vertebral column, sclerotome divides into cranial and caudal halves by an intersegmental fissure which marks where the intervertebral disc will form
DEVELOPMENT OF VERTEBRAE
what happens to the most cranial sclerotomes?
4 most cranial sclerotomes merge and form the occipital bone rather than forming vertebrae
DEVELOPMENT OF VERTEBRAE
what happens after the intersegmental tissue of each sclerotome?
2 halves (one top and one bottom) of adjacent sclerotomes merge and condense to form the perichordal disc = contributes to intravertebral discs and the body of vertebrae
EXPERIMENTAL:
how do we know that somites are specified to a specific vertebra?
if you transplant a somite from one regional to another, it will still form the same vertebra as before
DEVELOPMENT OF VERTEBRAE
how does chondrification occur in week 6?
first the vertebral bodies start to chondrify
then each half of the vertebral arch chondrites from a centre at their base = they meet at month 4 but a neurocentral joint between them remains for the first few years
DEVELOPMENT OF VERTEBRAE
what happens in puberty?
in puberty, secondary ossification centres appear in the spinous and transverse process
epiphyseal discs form/fuse at the cranial and caudal ends of the vertebral bodies
CLINICAL:
Explain spina bifida
when neural tube fails to close at the limbo-sacral region
this causes the meninges and spinal cord to bulge out
STRUCTURE AND FUNCTION OF VERTEBRAL COLUMN AND SPINAL NERVES
what is the function of the vertebral column?
vertebral column bears weight, allows mobility and protect the spinal cord
STRUCTURE AND FUNCTION OF VERTEBRAL COLUMN AND SPINAL NERVES
how many vertebrae are there
33 total
7 cervical 12 thoracic 5 lumbar 5 sacral (fused) 4 coccygeal