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Anatomy > Reproductive System Dev > Flashcards

Reproductive System Dev Flashcards

1
Q
  1. where does the gonadal ridge develop
A

intermediate mesoderm

week 7

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2
Q
  1. what is the gonadal ridge
A

Mesonephric mesenchyme covered in epithelium

Medial to Wolffian/Mullerian ducts

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3
Q
  1. what does the gonadal ridge develop into
A

primitive sex cords

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4
Q
  1. what happens to primordial germ cells?
A

Primordial germ cells from epiblast move through yolk sac’s endodermal wall

they migrate to the ends of the genital ridge

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5
Q
  1. how is the sex cord formed?
A

genital ridge epithelium penetrates mesenchyme beneath

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6
Q
  1. CLINICAL: what is a teratoma?
A

misdirected germ cells -> tumours

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7
Q
  1. what happens to developed sex cords
A

Sex cords proliferate -> horse-shoe testis cords surrounding primordial germ cells

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8
Q
  1. what happens to primordial germ cells?
A

Primordial cells concentrate In medulla
cortex degenerates

Cells around germ cells differentiate -> Sertoli due to SRY expression on Y chromosome

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9
Q
  1. what do Sertoli cells do?
A

secrete AMH - regress the paramesonephric/Müllerian duct

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10
Q
  1. what happens to mesoderm between the testes cords?
A

differentiate into leydig cells

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11
Q
  1. what do leydig cells do?
A

secrete testosterone = develop mesonephric/wolffian ducts

AT PUBERTY: they develop into the seminiferous tubules of the testis

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12
Q
  1. where do wolffish ducts drain
A

into the bladder

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13
Q
  1. how do wolffian ducts develop
A

testosterone:

vas deferens, seminal vesicles, prostate, epididymis, ejaculatory duct

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14
Q
  1. what is the final step of foetal genital development in males?
A

descent of testes

guided by gubernaculum band via inguinal canal

processus vaginalis envelops the testis to form the scrotum

gubernaculum regresses

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15
Q
  1. what hormone is needed for the development of external genitalia, the prostate and seminal vesicles?
A

5alpha-reductase converts T to DHT

DHT has higher affinity for androgen receptors than testosterone

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16
Q
  1. how is initial external genitalia the same for M and F
A

the genital tubercle at the top
the labioscrotal swellings on the side
and the urethral folds in the middle.

17
Q
  1. what does DHT do?
A

Genital tubercle elongates a lot-> phallus -> penis

Urethral sinus closes

Genital swellings -> scrotal swellings

18
Q

CLINICAL: genetic abnormality

A

XX males
SRY translocation to X
Infertile

19
Q
  1. describe the blood supply to developed testis
A

descendinng aorta > testicular arteries

20
Q
  1. describe venous drainage to developed testis
A

RIGHT:
testicular vein > IVC

LEFT:
testicular vein > left renal vein

21
Q
  1. where does lymph of testis go?
A

para-aortic lymph nodes

CLINICAL: cancers will spread to near the aorta

Anatomy (11 decks)

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