Spinal Reflexes Flashcards

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1
Q

What is a lower motor neurone?

A

A neurone which has its cell body in the ventral horn of the spinal cord

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2
Q

What is an upper motor neurone?

A

Neurones which send axons down the spinal cord in descending tracts to synapse on the cell bodies and dendrites of the lower motor neurones. These neurones have cell bodies in the brain which project down to the lower motor neurones and some also have their cell bodies

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3
Q

What are the three main types of synaptic input to lower motor neurones?

A

Descending tracts in the spinal cord from upper motor neurones, input from local inter neurones (cells with all their processes inside the CNS, grey matter) and Input from local sensory nerve fibres via reflexes

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4
Q

What are the two systems of upper motor neurones?

A

Pyramidal and extra-pyramidal systems

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5
Q

Describe the pyramidal system of upper motor neurones

A

Where upper motor neurone cell bodies project directly from the motor cortex of the brain to the spinal cord and travel via the corticospinal tract (pyramidal tract) to lower motor neurones

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6
Q

Describe the extra-pyramidal system of upper motor neurones

A

Where the upper motor neurone cell bodies in the brainstem project into the spinal cord and these motor neurones are regulated by the motor cortex

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7
Q

Describe the system of lower motor neurones

A

The spinal cord has lower motor neurones in the ventral horn that project out via peripheral nerves to muscles

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8
Q

What is the muscle spindle?

A

The muscle spindle is the receptor that mediates all of the tendon reflexes and is often called a proprioceptor as it responds to movements of the body rather than external stimuli

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9
Q

What is a reflex?

A

An involuntary motor action triggered by a sensory input. Can think about them as tiny ‘motor programmes’ which are stored in the synaptic connections between sensory inputs, outputs and interneurones in one or two spinal cord segments

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10
Q

Name the different reflex inputs

A

Descending axons of upper motor, sensory inputs, interneurones in other parts of the spinal cord

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11
Q

What are interneurons?

A

This may be excitatory or inhibitory to produce EPSPs or IPSPs

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12
Q

What are monosynaptic reflexes? Give examples

A

No interneurones are involved, and this makes it difficult for the brain to suppress these reflexes. Examples: myotactic knee, ankle, triceps, biceps and supination reflexes as

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13
Q

What is the evolutionary value of monosynaptic reflexes?

A

They are used by the brain as a form of negative feedback in order to maintain a constant muscle length despite ongoing muscle fatigue.

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14
Q

What is reciprocal inhibition in tendon reflexes?

A

Ordinarily, the same tendon tap that activates the (extensor) reflex will also inhibit the antagonist flexor through the action of an inhibitory neurones, so that when the extensor contracts in the reflex, the flexor relaxes to allow an unimpeded motion, and this is known as reciprocal inhibition.

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15
Q

Describe the basic structure of the muscle spindle

A

Spindle consists of a stretch receptor inside a connective tissue sheath, and the stretch of the muscle also stretches the muscle spindle within the sheath, activating sensory afferents (Ia sensory afferent predominantly)

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16
Q

How do muscle spindles act as muscle length detectors?

A

Spontaneously active at resting muscle lengths –> when muscle stretched –> increase firing rate on sensory afferents (Ia)

17
Q

Describe the role of the muscle spindle in reflexes, using the example of the patella reflex

A

Tapping patellar tendon –> burst of action potentials in several muscle spindles in the muscle (sensory Ia afferents) –> burst of APs acts on dendrites of the motor neurones on the quadriceps (alpha motor neurones) –> spatial and temporal summation on the motor neurones–> motor neurones each fire a single action potential –> muscle twitch

18
Q

Describe the detailed structure of the muscle spindle

A

Consists of modified skeletal muscle fibres within the capsule (intrafusal fibres), and all contractile tissue is at their ends, therefore the centre of the fibre doesn’t have actin or myosin but is full of cell bodies and mitochondria. Centre of fibre has no CT so can be easily stretched and Ia sensory afferents are located here

19
Q

What is the role of gamma motor neurones to the muscle spindle?

A

When stimulated, these motor neurones cause the ends of the intrafusal fibres to contract and therefore stretch the centre –> adjusts the sensitivity of the Ia afferents to stretch (gamma motor neurones increase afferent’s sensitivity to stretch)

20
Q

What does a pathological increase in gamma motor neurone activity lead to?

A

Hyperactive tendon reflexes

21
Q

Where is the Golgi tendon organ found?

A

In the muscle tendons

22
Q

What is the main role of the Golgi tendon organ?

A

Detect muscle tension

23
Q

What is the interneurone between the GTO and muscle known as?

A

Glycinergic inhibitory neurone

24
Q

How does the GTO respond when the tension in a tendon reaches a dangerous level?

A

Ib afferents detect this and send action potential to the glycinergic inhibitory neurone to act as a strong inhibitory of the alpha motor neurone to the muscle to inhibit muscular contraction –> switches of the muscle

25
Q

Why is the monosynaptic reflex easiest to elicit in leg extensors?

A

It has the fastest feedback response as there is a need for maximum postural stability and agility in these muscles in order to maintain standing (else we would always fall over)

26
Q

What type of reflexes are monosynaptic?

A

Extension reflexes

27
Q

What type of reflexes are polysynaptic?

A

Flexion reflexes

28
Q

What are crossed extensor reflexes?

A

The activation of extensors in the other leg during a flexion reflex in order to transfer body weight - this is a polysynaptic reflex

29
Q

What is the physiology behind crossed extensor reflexes?

A

Afferent nerve fibres cross from stimulated side to the contralateral side of the spinal cord –> synapse with interneurons –> excite or inhibit alpha motor neurones to the muscles of the contralateral limb

30
Q

Describe polysynaptic reflexes

A

Stimulated afferents (often nociceptors) synapse on interneurons in the spinal cord (2/3 excitatory interneurons are often required) –> alpha motor neurone to flexor. Therefore these reflexes can be suppressed by the brain due to may interneurones

31
Q

What is muscle tone?

A

The normal level of resistance elicited by the muscles to passive movement, due to small amounts of contraction in muscles (even in full patient co-operation)

32
Q

What is ‘flaccid paralysis’

A

Absence of any muscle tone (no basal resistance to passive movement)

33
Q

What is spasticity?

A

Exaggerated reflexes and increased muscle tone (more resistance to passive movement; appears like stiffness)

34
Q

What type of reflex is the cross-extensor reflex?

A

Polysynaptic