Spinal cord lesions

Question 1

What nucleotide and chromosome affected in Friedreich ataxia?

Answer 1

GAA, 9 chromosome

Question 2

What is the death reason in Friedreich ataxia?

Answer 2

Hypertrophic cardiomyopathy

Question 3

Friedreich ataxia: damaged dorsal column. What symptoms?

Answer 3

Decr. vibratory and proprioreception.

Question 4

Friedreich ataxia: damaged dorsal root ganglia. What symptoms?

Answer 4

Deep tendons reflexes.

Question 5

Friedreich ataxia: damaged lateral corticospinal tract. What symptoms?

Answer 5

Spastic paralysis. In pathoma: weakness in the lower extremities.

Question 6

Friedreich ataxia: damaged spinocereberal tract. What symptoms?

Answer 6

Ataxia

Question 7

Where replicates poliovirus?

Answer 7

fecal-oral transmition. Replicates in oropharynx and small intestine before enters bloodstream and reaches the CSF.

Question 8

What is damaged in poliomyelitis?

Answer 8

Anterior motor horn. (LOWER MOTOR NEURONS)

Question 9

Symptoms of poliomyelitis?

Answer 9

Asymetric weakness, hypotonia, flaccidic paralysis, fasciculations, hyporeflexia, muscle atrophy. Respiratory muscle involvement –> resp. failure.

Question 10

CSF Labs. in poliomyelitis?

Answer 10

CSF: incr. WBC (lymphocytic pleocytosis) and slightly increased proteins. NO CHANGE IN GLUCOSE.

Question 11

Leptomeninges consist of …………… and ……………….

Answer 11

Pia and arachnoid