Degenerative Flashcards
Degeneration of cortex leads to ……………
DEMENTIA
Degeneration of the brainstem and basal ganglia leads to ……………
MOVEMENT DISORDERS
What is the most common disorder of dementia?
Alzheimer disease (AD)
Why Down syndrome patients have increased risk of Alzheimer disease?
Because in AD important role plays ABeta amyloid, which is product of APP (amyloid precursor protein). APP is encoded in 21 chromosome.
Lewy bodies in Parkinson disease are composed of ………….
alpha-synuclein
Movement disorders, such …………… and ………….. are due to degeneration of ………………………. and …………………
Parkinson and Huntington; brainstem and basal ganglia
Dementia is due to degenration of ………………………
Cortex
What important structure degenerates in AD, that is important for memory?
Hippocampus
Neuritic plaques are extra or intracellular?
Extra
Neurofibrillary tangles are extra or intracellular?
Intra
Why there is decreased ACh in AD?
Due to the loss of cholinergic neurons in the nucleus basalis of Meynert
What neurons are lost in Parkinson’s disease?
Dopaminergic
What neurons are lost in Huntington’s disease?
GABAergic
Where are the neurons, that are lost in Parkinson’s disease?
In substantia nigra of basal ganglia. It’s dopaminergic neurons.
Where are the neurons, that are lost in Huntington’s disease?
In nucleus caudatus of basal ganglia. It’s GABAergic neurons.
