Spectrum of AI disease Flashcards
AICTDs
MCTD
SLE
SSclerosis
DM/PMyositis
Sjrogens syndrome
What antibody is positive in most AICTDs
ANA
Why does positive ANA not mean CTD
Frequency increases with age
Can be present without causing symptoms eg low levels in serum
Titre dependent
What staining can use for aCTD diagnosis
Bioplex
What is titre in staining
How diluted fluid is where antibody still detectable eg 1/40 not nearly as significant as 1/640
What type of staining is ass with SLE, Discoid LE
Homogenous staining
What histological features ass with SLE/DLE
antidsDNA
antihistone ab
homogenos pattern stain
What can be ass with speckled pattern of staining
Systemic sclerosis
SLE
Sjrogens
What DNA is diffuse systemic sclerosis ass with
RNA pol III
Scl-70
What antibody is SLE w speckled staining ass with
Smith antibody
What antibodies are ass with sjrogens syndrome in speckled histology
SSA (Ro)
SSB (La)
What diseases is dsDNA present in
SLE
AI hepatitis
What is autoimmune CTD is histone ass with
drug induced SLE
Disocid LE
What autoimmune CTDs are ass with nucleolar staining
Systemic sclerosis
Polymyositis
What antibody is limites systemic sclerosis ass with
antiCentromere
