Global burden of connective tissue disease

Question 2

investigations for Rheumatoid

Answer 2

FBC, inflam amrkers, U+Es, LFTs, autoantibody -antiCCP, Rf

Question 3

What imaging before rheumatoid drugs

Answer 3

CXR

Question 4

Rheumatoid arhtritis prevalence

Answer 4

1% of UK
More common in women
More ommon in UK than globally
42nd highest contributor to global disabilty

Question 5

Work disability and RA

Answer 5

40% work disability within 10 years

Question 6

Impact of RA

Answer 6

Reduced QOL
Joint replacement surgery
Development of other chronic diseases
Premature mortality vs general population
Development of chronic diseSES
Premature mortality w general pop

Question 7

How common is joint replacement therapy

Answer 7

25% patients JR in 20 years after disease onset

Question 8

Chronic diseases from RA

Answer 8

CVD, lungdiseases, psych disorders, osteoporosis and fractures, some malignancie eg lymphoma, lung and non melanotic skin cancers

Question 9

Costs of RA

Answer 9

Medical care, drugs, disability and work loss, Reduced QOL, premature mortality
37 billion globally a year

Question 10

Changing data

Answer 10

New drugs, developung countries etc

Question 11

SLE prevalence in asia vs UK

Answer 11

Chinese common, malaysia, indian - 43/100,000
Less common UK
>10,000

Question 12

Racial and gender SLE

Answer 12

Afro caribbean women more likley
8-10x more common in women than men

Question 13

Prevalence of SLE

Answer 13

Black ethnicity - highest incidence and prevalnce
Women more

Question 14

Prevalence =

Answer 14

proportion people have condition at or during particular time

Question 15

Incidence

Answer 15

Proportion or rate of people who develop a condition during a particular time period

Question 16

Rare CTD diseases

Answer 16

Primary sjrogens
Systemic sclerosis
Polymyositis/dermatomyositis
MCTD
Vasculitis