SLE Flashcards
SLE incidence
Peaks in 20-35 years, can occur any age
Strong genetic componenet
What drugs can cause drug induced lupus
Hydralazine
#Isoniazid,
Chlorpromazine
Minocycline
TNF inhibitors
Commonest symtpoms of lupus at presentation
Photosensitive rash - butterfly. Avoid rashes
Fatigue
Arthritis
Rash in myosistis vs SLE
SLE rasha avoids eyelids, myositis doesnt
Arthritis in SLE
Non deforming symmetroical polyarthropathy
Other symptoms of SLE
Alopecia - patches of baldness
Headahces
Sicca symptoms
Mouth ulcers
Pleurtitc pain
Raynauds phenomenon - blue or purple -> white -> redness
Recurrent miscarriages
Ass diseases with SLE
Renal disease
Neurological/psychiatric - psychosis, personality change
Haematological
Mimics many other conditions
Can affect any organ
Diagnosis of SLE
Hisotry and exam
Immunology - ANA
Invetigations for SLE
FBC, UEs, ESR/CRP
ANA ]dsDNA, complement C3+C4 - disease activity
Lupus anticoagulant + APS antibodies (clotting)
BP and urinarlysis
What can you use to monitor disease acitivty in lupus
Complemetn C3+4
dsDNA
Whateffect does increasing disease activity have on C3+C4 and dsDNA
Increase dsDNA
Decrease C3+C4
Complications of SLE
Renal disease
Obstetric comps including miscarriage
Thrombotic risk
Atheroscleroisis Complications of treatment
Treatment for SLE
NSAIDs
Sun block - sun increases disease activity
Nutrition
Smoking cessation
Steroids for flares
DMARDs
Biologics
DMARDs for SLE
Hydroxychloroquine
Methrotrecate, azathioprine, mycophenolate, cyclophosphamide
Biologic drugs for SLE
Rituximab
Belimumab
