SLE Flashcards
SLE incidence
Peaks in 20-35 years, can occur any age
Strong genetic componenet
What drugs can cause drug induced lupus
Hydralazine
#Isoniazid,
Chlorpromazine
Minocycline
TNF inhibitors
Commonest symtpoms of lupus at presentation
Photosensitive rash - butterfly. Avoid rashes
Fatigue
Arthritis
Rash in myosistis vs SLE
SLE rasha avoids eyelids, myositis doesnt
Arthritis in SLE
Non deforming symmetroical polyarthropathy
Other symptoms of SLE
Alopecia - patches of baldness
Headahces
Sicca symptoms
Mouth ulcers
Pleurtitc pain
Raynauds phenomenon - blue or purple -> white -> redness
Recurrent miscarriages
Ass diseases with SLE
Renal disease
Neurological/psychiatric - psychosis, personality change
Haematological
Mimics many other conditions
Can affect any organ
Diagnosis of SLE
Hisotry and exam
Immunology - ANA
Invetigations for SLE
FBC, UEs, ESR/CRP
ANA ]dsDNA, complement C3+C4 - disease activity
Lupus anticoagulant + APS antibodies (clotting)
BP and urinarlysis
What can you use to monitor disease acitivty in lupus
Complemetn C3+4
dsDNA
Whateffect does increasing disease activity have on C3+C4 and dsDNA
Increase dsDNA
Decrease C3+C4
Complications of SLE
Renal disease
Obstetric comps including miscarriage
Thrombotic risk
Atheroscleroisis Complications of treatment
Treatment for SLE
NSAIDs
Sun block - sun increases disease activity
Nutrition
Smoking cessation
Steroids for flares
DMARDs
Biologics
DMARDs for SLE
Hydroxychloroquine
Methrotrecate, azathioprine, mycophenolate, cyclophosphamide
Biologic drugs for SLE
Rituximab
Belimumab
What drug should everyone with SLE be on
Hydroxychloroquine
