Spectrum of activity broken down Flashcards
Methicillin-Susceptible Staphylococcus aureus (MSSA)
B-lactam drugs that cover
Nafcillin (IV), Oxacillin, Dicloxacillin (PO)
Unasyn, Zosyn
Cefazolin (IV)*, Cephalexin (PO), Cefuroxime (IV/PO), Ceftriaxone (?), Ceftaroline
Imipenem and Doripenem (rarely used for MSSA)
Methicillin-Susceptible Staphylococcus aureus (MSSA)
Macrolides that cover
Erythromycin, Clarithromycin, and Azithromycin (rarely used for MSSA)
Methicillin-Susceptible Staphylococcus aureus (MSSA)
FQ that cover
Levofloxacin and Moxifloxacin (rarely used for MSSA)
Methicillin-Susceptible Staphylococcus aureus (MSSA)
Gram positive and Vanc
Vancomycin† (only in patients who cannot receive β-lactams)
Quinupristin/Dalfopristin (Synercid©)
Linezolid, Tedizolid
Daptomycin
Telavancin, Dalbavancin, Oritavancin
Methicillin-Susceptible Staphylococcus aureus (MSSA)
miscellaneous drugs
Doxycycline, Minocycline, Tetracycline analogs (rarely used for MSSA)
Trimethoprim-sulfamethoxazole
Clindamycin
Methicillin-Resistant Staphylococcus aureus (MRSA)
Vanc and gram positive drugs
Vancomycin*
Quinupristin/Dalfopristin (Synercid)
Linezolid† (in patients who cannot tolerate vancomycin), Tedizolid
Daptomycin† (in patients who cannot tolerate vancomycin)
Telavancin, Dalbavancin, Oritavancin
Methicillin-Resistant Staphylococcus aureus (MRSA)
Cephalosporin
Ceftaroline
Methicillin-Resistant Staphylococcus aureus (MRSA)
Miscellaneous
Minocycline, Tetracycline analogs (rarely used for MRSA)
CA-MRSA SSTIs: Clindamycin, TMP-SMX, Delafloxacin
Enterococcus spp. Susceptible to Ampicillin and Vancomycin
Ampicillin* (IV or PO, depending on infection) and amoxicillin (PO, UTIs only)
Vancomycin† (only in patients who cannot receive ampicillin)
Quinupristin/Dalfopristin (Synercid)
Linezolid, Tedizolid
Daptomycin
Telavancin
Doxycycline and Tetracycline analogs (rarely used for Enterococcus)
Vancomycin-Resistant Enterococcus spp. (VRE) Resistant to Ampicillin
Linezolid* (only if patient not on SSRI and platelet count >50-100), Tedizolid
Daptomycin* (if patient on SSRI)
Quinupristin/Dalfopristin (Synercid©) – 3rd line, only active against VRE faecium
Oritavancin
Pseudomonas aeruginosa
B-lactam
Ticarcillin
Piperacillin*
Piperacillin-tazobactam (Zosyn©)
Ceftazidime, Cefepime*, Cefiderocol
Meropenem or Doripenem†
Aztreonam
Pseudomonas aeruginosa
FQ
Ciprofloxacin, Levofloxacin, Delafloxacin
Pseudomonas aeruginosa
aminoglycosides
Gentamicin, Tobramycin or Amikacin* (primarily in combination with β-lactams)
Pseudomonas aeruginosa
polymyxin
Colistin, Polymyxin b
Atypical Bacteria such as Legionella, Mycoplasma, Chlamydia
Macrolides
Erythromycin, Clarithromycin or Azithromycin*
Atypical Bacteria such as Legionella, Mycoplasma, Chlamydia
FQ
Levofloxacin, Ciprofloxacin, Delafloxacin, Moxifloxacin*
Atypical Bacteria such as Legionella, Mycoplasma, Chlamydia
Tetracyclines
Doxycycline† and Tetracycline analogs
Monomicrobial infection due to Bacteroides spp
Metronidazole*
Clindamycin
Unasyn© or Zosyn©†
Imipenem, Meropenem, Doripenem or Ertapenem†
Polymicrobial infection with Bacteroides spp. and Gram-negative aerobes
B-lactam
Unasyn© alone (limited gram-negative coverage)
Zosyn© alone*
Imipenem, Meropenem, Doripenem or Ertapenem alone†
Cefoxitin or Cefotetan alone
Ceftriaxone or Cefepime with Metronidazole†
Polymicrobial infection with Bacteroides spp. and Gram-negative aerobes
FQ
Tetracyclines
Ciprofloxacin or Levofloxacin with Metronidazole†
Tetracycline analogs
Clostridioides difficile colitis
Oral Vancomycin
Metronidazole
