Cushman

Question 1

Production of Sulfanilamide

Answer 1

Prontosil is broken down by bacteria and creasted sulfanilamide

Question 2

Structure relationship

Answer 2

the attachement of electron withdrawling heteroaromatic rings acidified the sulfonamide nitrogen and enhanced the potency

Increase acidity is due to the electronegativity of the aromatic substituent

The increase in acidity also decreases the incidence of crystalluria

Question 3

DHFR gene mutation

Answer 3

bears mutation that enables the expressed enzyme to be active in the presence of drug through a decreased binding affinity of trimethoprim

Question 4

Metabolism

Answer 4

Metaboloized by N-4 N-acetylation and in some cases N-1 Glucuronidation

Question 5

Colistin

Answer 5

Contains 2,4-diaminobutanoic acid residues that are protonated at physiological pH