Spectrum of Activity Abx

Question 1

What antibiotics cover atypicals?

Answer 1

"DAFT"
•     Doxycycline
•     Azithromycin (Zithromax)
•	FQs: (L and M: good; C: moderate) 
•     Tygacil

Question 2

What antibiotics cover anaerobes?

Answer 2

"Z-FACT"
•     Zosyn
•     Flagyl
•	Avelox and ampicillin/sulbactam 
•	Clindamycin and carbapenems 
•     Tygacil

Question 3

What antibiotics cover pseudomonas?

Answer 3

"GAZe into the C"
Gentamicin
Aztreonam
Zosyn
except Ertie

Carbapenems
Ceftazidime
Cefepime
Cipro

Question 4

Which gram (-) bugs do 3rd generation cephalosporins cover?

Answer 4

Gram Negatives covered: “HeN PEcK”
	H. flu
	Nisseria
	Proteus
	E. coli
	Klebsiella

Question 5

Which gram (-) bugs do 1st generation cephalosporins cover?

Answer 5

PEcK → proteus, E. coli, klebsiella

Question 6

Nafcillin

Answer 6

most gram (+) aerobes
(NOT MRSA or enterococcus)

Question 7

Ampicillin/Sulbactam

Answer 7

• cover most gram (+) aerobes including enterococcus but not MRSA
• covers most gram (-) aerobes (NOT pseudomonas)
• covers anaerobes

Question 8

Which drug has good activity against Acinetobacter baumannii, a high drug-resistant GNR?

Answer 8

Ampicillin/Sulbactam

Question 9

Zosyn

Answer 9

most gram (+) aerobes including enterococcus (NOT MRSA), covers most gram (-) aerobes including pseudomonas, also covers anaerobes

Question 10

Keflex and Ancef

Answer 10

Covers most Gram (+) and (-) aerobes
• Gram (-): PEcK → proteus, E. coli, klebsiella

Does NOT cover MRSA, enterococcus or pseudomonas

Question 11

Cefuroxime (Ceftin)

Answer 11

Cover most Gram (+) and (-) aerobes

Does NOT cover MRSA, enterococcus or pseudomonas

Question 12

Ceftriaxone

Answer 12

• cover most gram (+) aerobes (not including enterococcus or MRSA)
• covers most gram (-) aerobes (NOT pseudomonas)

Question 13

Cefotaxime

Answer 13

• cover most gram (+) aerobes (not including enterococcus or MRSA)
• covers most gram (-) aerobes (NOT pseudomonas)

Question 14

Ceftazidime

Answer 14

covers most gram (-) aerobes (including pseudomonas!)

Question 15

cefepime

Answer 15

 cover most gram (+) aerobes (not including enterococcus or MRSA)
 covers most gram (-) aerobes (including pseudomonas)

Question 16

Ceftaroline fosamil

Answer 16

Cover most Gram (+) aerobes
o Covers MRSA
o Does NOT cover enterococcus

Question 17

Carbapenems

Answer 17

• Gram (+) aerobes (enterococcus except Ertie)
• Gram (-) aerobes (pseudomonas except ertie)
• anaerobes!
• None cover MRSA

Question 18

Aztreonam (Azactam)

Answer 18

covers most gram (-) aerobes (including pseudomonas)

Question 19

Vancomycin

Answer 19

MRSA!!!

gram (+) [including MRSA & enterococcus]; oral form covers C. diff

Question 20

Telavancin

Answer 20

gram (+) [including MRSA & enterococcus]

Question 21

Daptomycin

Answer 21

gram (+) [including MRSA & enterococcus]

Question 22

Clindamycin

Answer 22

gram (+) [including MRSA, but NOT enterococcus]; covers anaerobes

Question 23

Azithromycin

Answer 23

covers most gram (+) aerobes (not including enterococcus or MRSA)

covers some gram (-) aerobes (does not cover pseudomonas)

• only covers gram (-) found in the respiratory track (H. Flu, M. Cat)
• does NOT cover e.coli, proteus, etc.
  
  covers atypicals

Question 24

Flagyl

Answer 24

Anaerobes (poor enterococcus coverage)

Question 25

Bactrim

Answer 25

gram (+) aerobes [including MRSA] • Does not cover enterococcus  gram (-) aerobes (except pseudomonas)

Question 26

Cipro

Answer 26

o does NOT cover most gram (+) aerobes but covers enterococcus in the urine o covers MOST gram (-) aerobes and PSEUDOMONAS

Question 27

Levaquin

Answer 27

does NOT cover most gram (+) aerobes but covers enterococcus in the urine covers MOST gram (-) aerobes (pseudomonal coverage is debatable) Atypicals (good coverage)

Question 28

Avelox

Answer 28

o covers most gram (+) aerobes but does not cover enterococcus o covers MOST gram (-) aerobes (does NOT cover pseudomonas) o covers atypicals o Moxifloxacin has moderate coverage of anaerobes

Question 29

Rifampin

Answer 29

MRSA

Question 30

Doxycycline

Answer 30

covers gram (+) aerobes including MRSA, but not enterococcus covers atypicals

Question 31

Tigacycline

Answer 31

covers gram (+) aerobes including MRSA & enterococcus covers most gram (-) aerobes (NOT pseudomonas) also covers anaerobes and atypicals (EVERYTHING but pseudomonas)

Question 32

Gentamicin

Answer 32

Gram NEGATIVES covers most gram (-) aerobes including pseudomonas; if combined with a ß-lactam, gent can help cover most Gram (+) aerobes, including enterococcus (does not cover MRSA)