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Oncology Boards > Specifically mentioned papers > Flashcards

Specifically mentioned papers Flashcards

1
Q

What xenogenic plasmid DNA targets were evaluated?

A 
huTyr
murine GP75
muTry
muTry+/-HuGM-CSF
(diff concentrations used)
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2
Q

A 2-5 fold increase in antibodies is documented in response to what?

A

huTyr

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3
Q

Which vaccine was associated with longest MST and what was it?

A

huTyr and 389 d

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4
Q

For dogs with OMM stage 2-3 with local control, what is MST of all vaccines?

A

569d

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5
Q

What are two molecules involved in cell contact growth inhibition?

A

NF2 (couples E-cad to transmembrane RTK)

LKB1 (epithelial polarity protein)

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6
Q

When LKB1 expression is suppressed, epithelial cells become more susceptible to what oncogene?

A

myc

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7
Q

In health what is main effect of TGFbeta on proliferation?

A

antiproliferation

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8
Q

which caspase is activated by the intrinsic and extrinsic apoptotic pathways?

A

intrinsic: 9
extrinsic: 8

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9
Q

Bcl2, BclxL, bclw, Mcl1 and A1 impact apoptosis in what way?

A

antiapopotic

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10
Q

Bax and Bak have what role?

A

pro apopotic and result in disruption of mitochondrial membrane integrity and release of cytochrome C and other substances

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11
Q

What does p53 upregulate as part of apoptotic pathway?

A

Noxa and Puma

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12
Q

What changes result in Bim activation?

A

insufficient survival signals (low IL3 in lymphocytes or low IGF1/2 in epithelial cells)

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13
Q

T/F hyperactivation of myc does not lead to apoptosis

A

false it does unless anti-apoptotic factor present

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14
Q

what is the most common strategy to avoid apoptosis?

A

loss of p53

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15
Q

Beclin-1 release from Bcl2/BclxL results in what?

A

autophagy

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16
Q

T/F Autophagy can be both tumor promoting and tumor suppressive

A

True

17
Q

What DNA feature is integral to replicative immortality?

A

telomeres

18
Q

what is the role of telomerase?

A

prevents telomere erosion

19
Q

maintenance of telomere length induces resistance to what two processes?

A

senescence and apoptosis

20
Q

T/F Telomere erosion can be protumorigenic

A

true

21
Q

T/F TERT only has activity in telomere maintenance

A

false- also cofactor of B catenin/LEF transcription factor complex, cell proliferation and resistance to apoptosis, DNA damage repair and RNA dep RNA polymerase fxn as well

22
Q

What two features increase VEGF expression?

A

hypoxia and oncogene signaling

23
Q

What is the role of thrombospondin 1?

A

antiangiogenic

24
Q

What are the main steps to metastasis?

A 
local invasion
intravasation
transit
extravasation
micrometastasis
colonization
25
Q

What transcription factors are associated with EMT?

A

snail, slug, twist, zeb1/2

26
Q

EMT process up or down regulates E-cadherin?

A

downregulates

27
Q

What additional cells, aside from neoplastic, are involved in invasion and metastasis?

A

TME - macrophages, MSC etc

28
Q

T/F EMT is an irreversible one way process

A

false can undergo MET or partial EMT etc

29
Q

What are ways in which micromets may be dormant?

A

inability to activate angiogenesis
nutrient starvation
anti-growth signals in ECM
immune system suppression

30
Q

Telomerase activity applies to what two hallmarks?

A

unlimited replication

genomic instability

31
Q

What is one way cells facilitate glucose requirements for increased aerobic glycolysis?

A

increased GLUT1

32
Q

What are some unique features of CSC?

A

ability to regenerate/repopulate tumor

resistance to anticancer therapy

33
Q

what are two vascular cells in TME?

A

endothelial cells and pericytes

34
Q

what are two types of cancer associated fibroblasts?

A

tissue derived

myofibroblasts (SMA expression)

35
Q

What translocation occurs w/ burkitt’s LSA?

A

IgH and myc

36
Q

what results in constitutive myc activation?

A

CFA13 amplification

37
Q

CLL has what mutation?

A

CFA 22 - deletion Rb

Oncology Boards (4 decks)

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