Specifically mentioned papers Flashcards
What xenogenic plasmid DNA targets were evaluated?
huTyr murine GP75 muTry muTry+/-HuGM-CSF (diff concentrations used)
A 2-5 fold increase in antibodies is documented in response to what?
huTyr
Which vaccine was associated with longest MST and what was it?
huTyr and 389 d
For dogs with OMM stage 2-3 with local control, what is MST of all vaccines?
569d
What are two molecules involved in cell contact growth inhibition?
NF2 (couples E-cad to transmembrane RTK)
LKB1 (epithelial polarity protein)
When LKB1 expression is suppressed, epithelial cells become more susceptible to what oncogene?
myc
In health what is main effect of TGFbeta on proliferation?
antiproliferation
which caspase is activated by the intrinsic and extrinsic apoptotic pathways?
intrinsic: 9
extrinsic: 8
Bcl2, BclxL, bclw, Mcl1 and A1 impact apoptosis in what way?
antiapopotic
Bax and Bak have what role?
pro apopotic and result in disruption of mitochondrial membrane integrity and release of cytochrome C and other substances
What does p53 upregulate as part of apoptotic pathway?
Noxa and Puma
What changes result in Bim activation?
insufficient survival signals (low IL3 in lymphocytes or low IGF1/2 in epithelial cells)
T/F hyperactivation of myc does not lead to apoptosis
false it does unless anti-apoptotic factor present
what is the most common strategy to avoid apoptosis?
loss of p53
Beclin-1 release from Bcl2/BclxL results in what?
autophagy
T/F Autophagy can be both tumor promoting and tumor suppressive
True
What DNA feature is integral to replicative immortality?
telomeres
what is the role of telomerase?
prevents telomere erosion
maintenance of telomere length induces resistance to what two processes?
senescence and apoptosis
T/F Telomere erosion can be protumorigenic
true
T/F TERT only has activity in telomere maintenance
false- also cofactor of B catenin/LEF transcription factor complex, cell proliferation and resistance to apoptosis, DNA damage repair and RNA dep RNA polymerase fxn as well
What two features increase VEGF expression?
hypoxia and oncogene signaling
What is the role of thrombospondin 1?
antiangiogenic
What are the main steps to metastasis?
local invasion intravasation transit extravasation micrometastasis colonization
What transcription factors are associated with EMT?
snail, slug, twist, zeb1/2
EMT process up or down regulates E-cadherin?
downregulates
What additional cells, aside from neoplastic, are involved in invasion and metastasis?
TME - macrophages, MSC etc
T/F EMT is an irreversible one way process
false can undergo MET or partial EMT etc
What are ways in which micromets may be dormant?
inability to activate angiogenesis
nutrient starvation
anti-growth signals in ECM
immune system suppression
Telomerase activity applies to what two hallmarks?
unlimited replication
genomic instability
What is one way cells facilitate glucose requirements for increased aerobic glycolysis?
increased GLUT1
What are some unique features of CSC?
ability to regenerate/repopulate tumor
resistance to anticancer therapy
what are two vascular cells in TME?
endothelial cells and pericytes
what are two types of cancer associated fibroblasts?
tissue derived
myofibroblasts (SMA expression)
What translocation occurs w/ burkitt’s LSA?
IgH and myc
what results in constitutive myc activation?
CFA13 amplification
CLL has what mutation?
CFA 22 - deletion Rb
