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oncology boards > Committee papers > Flashcards

Committee papers Flashcards

1
Q

Rare SE of lspar reported in a dog?

A

pancreatitis

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2
Q

RR and PFS for rescue MOMP

A

50%; 56 d

no diff T vs B cells

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3
Q

What do all melanoma in dogs and cats express?

A

tyrosinase - no correlation w/ pigment, MHC1, or histo claasification

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4
Q

Which cells does IL12 cytokine activate?

A

Th1 and Tc

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5
Q

What is NHS-IL12?

A

immuncytokine of ab targeting necrotic tumor regions, linked ot IL12

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6
Q

What AE are noted with NHS-IL12 in dogs with melanoma?

A

thrombo, elevated LE, fever, vasculitis

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7
Q

IL10 and intratumoral CD8 cell decreased or increased with NHS-IL12 in melanoma?

A

increased

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8
Q

what is the tolerable dose of NHS-IL12?

A

0.8mg/mg2 SQ q 28 d (if response)

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9
Q

If untx how many melanomas in horses become malignant?

A

2/3rd

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10
Q

what is MC skin tumor in horses?

A

melanoma (gray horses)

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11
Q

Scottish deerhounds have possible linkage between phenotype and markers on what chromosome associated with OSA?

A

Chr. 34

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12
Q

what is incidence of OSA in scottish deerhounds?

A

> 15%

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13
Q

What were prog factors for scottish deerhounds and OSA?

A

gender and genotype

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14
Q

in solid tumors, to what depth can hyperthermia reach therapeutic levels?

A

> 4cm

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15
Q

What is MR appearance of canine MCT?

A

most hyperintense on T2 and isointense T1 and all CE

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16
Q

Is there a sig diff in MRI features of metastatic MCT LN?

A

mets larger and generally more heterogenous (but not stat sig)

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17
Q

What type of LSA is reported in yellow naped Amazon parrot?

A

GI T cell LSA

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18
Q

What is MTD for palladia and dox combination?

A

25mg/m2 dox q 21 d

DLT neutropenia

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19
Q

what was CR, PFS and MST of 12 week vs 19 weeks CHOP?

A

90% CR in both (95% ORR)

  • 12 wk PFS 141 d and 19 wk 208 d
  • 12 wk MST 234 d vs 348d
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20
Q

what is diff in DI in 12 week vs 19 week CHOP?

A

58% increased DI for dox and cytoxan vs 21% reduced for vinc

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21
Q

what is MC small cell GI LSA In cats?

A

CD3+ w/ epitheliotropism

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22
Q

what is ORR and duration in cats w/ small cell GI LSA?

A

96% with MST 786d

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23
Q

what % of dogs with cut OSA mets have mets to lung and bone?

A

86% lung

5% bone

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24
Q

what was time to develop and MST of cut OSA mets in dgos?

A

160 days with MST 55 days

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25
Q

what was MST for cut OSA mets tx w/ sx + chemo vs chemo vs supportive?

A

3mn vs 2mn vs 11d

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26
Q

What is MTD carbo + palladia

A

200mg/m2

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27
Q

What enzymes are directly inhibited by Zinc oxide?

A

ERK and AKT

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28
Q

What unique features does Zinc oxide have?

A

unique surface
ROS induction
lipid peroxidation
pH/ionic gradient changes in cancer cells and microenvironment

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29
Q

What was successful tx of a oral FSA in an alpaca?

A

sx followed by RT after recurrence resulted in >2 yr ST (110 weeks)

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30
Q

What drug and where was contamination found at VTH?

A

carboplatin on biological safety cabinet

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31
Q

What features were used to develop risk score for dogs w/ hemoabd?

A

weight, plasma protein, platelet count and CXR

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32
Q

Using HeLP score, what % of HSA in low, medium and high risk groups?

A

36%
76%
96%

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33
Q

Of malignant splenic tumors, how common are they HSA in small (<27.8kg) and large dogs?

A

46% small

65% large

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34
Q

What findings were more common in all dogs dx with splenic HSA?

A

preop anemia
hemoab
thrombo
blood transfusion

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35
Q

In canine nasal tumors, what RTK is phosphorylated?

A

EGFR1 most common

NOT VEGFR2, PDGFR alpha/beta, cKIT

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36
Q

What is mechanism of palladia efficacy in canine nasal tumors?

A

unknown -not likely VEGFR, PDGFR or kit as not phosphorylated

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37
Q

What is ORR and MST for intermittent single agent dox in BCL?

A

78% RR

MST 170d

38
Q

Does gadoxetate disodium contrast enhanced MRI find more or less lesions than usual MRI for HCC?

A

yes ID new lesions in 3/7 patients

39
Q

With gadoxetate disodium contrast MRI of livers, a signal intensity ratio of <1 indicates what?

A

retained but impaired liver fnx

40
Q

what small breed dog is predisposed to HS?

A

mini schnauzers

41
Q

What may predispose mini schnauzers to HS?

A

inherited risk factor likely based on pedigree analysis

42
Q

what is OR of prior joint dz in a limb affected by periarticular HS vs control dogs?

A

13.42

43
Q

How commonly did stifle joints with PAHS have dz and what was most common?

A

88% - CrCL rupture

44
Q

what is RR for combination CCNU/dox for HS and MST?

A

58%

185d

45
Q

Substitution of mito for dox in first line tx of canine LSA had was ORR, PFI and MST?

A

CHOP 97%, PFI 208; MST 348d

CMOP 100%, PFI 165; MST 234

46
Q

What is RV1001?

A

PI3K inhibitor

47
Q

What tumor type and RR has been noted with RV1001?

A

LSA in dogs with 62% and 77% RR

48
Q

what was main toxicity of RV1001?

A

hepatobiliary (DLT) and GI

49
Q

what is most common initial diagnosis for lingual TZL?

A

plasma cell tumor

50
Q

what clinical findings and outcome were noted with lingual TZL?

A

11/12 lymphocytosis +/- LN involvement

7/12 CR and 4/12 SD

51
Q

What is RR and MST for canine small cell GI LSA?

A

70%

424d

52
Q

What is most common phenotype of small GI LSA in dogs?

A

T cell (95%) with 60% epitheliotropic

53
Q

Protein kinase CK2 is increased or decreased in cancer?

A

increased

54
Q

what is tenfibgen and what is it’s use?

A

ligand to target Tenascin-C receptors - used to deliver siRNA targeting protein kinase CK2 to tumor tissue

55
Q

What is ORR for cats with MM to chemotherapy?

A

71-83% (melphalan vs cytoxan)

56
Q

What is MST for cats with MM tx with cytoxan and melphalan and were they different?

A

cytoxan 13mn
melphalan 8mn
Not diff

57
Q

What is the role of protein kinase CK2?

A

activate NFkB, WNT-B catenin, PI3K-AKT pathway, inactivate tumor suppressors (PTEN) and suppress apoptosis

58
Q

what feline tumor type expresses protein kinase CK2 and what occurs with inhibition in vitro?

A

SCC

siRNA targeting resulted in decrease viability and apoptosis

59
Q

What the important targets on protein kinase CK2?

A

CK2alpha (most important) and CK2alpha’

60
Q

Was tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets effective?

A

2 samples reduced IHC score

61
Q

what were SE of tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets

A

MC grade 1-2 weight loss/anorexia; gr 3 necrosis in 1 cat and asymp gr 4 ALT and CK

62
Q

Does tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets induce tumor response?

A

1 PR and 3 SD in feline OSCC

63
Q

T/F Aurora kinase inhibitors are effective in OSA cell lines

A

false

64
Q

Vinblastine as 2nd rescue for canine LSA has what RR and PFS?

A

25%

PFS 30d

65
Q

MRI signal intensity of what organs may diff btw hematopoiectic neoplasia?

A

visual and ROI evaluated liver < skeletal muscle in affected (healthy > than skeletal muscle)

66
Q

what is the DFS and MST for OSA dogs tx w/ amputation, carbo, MC +/- palladia?

A

w/o palladia: DFI 215d nad MST 242d

w/ palladia DFI 233 and 318 (no diff)

67
Q

What was 1 yr survival for OSA dogs tx w/ amputation, carbo, MC +/- palladia?

A

38% and 35%

68
Q

contoured BSA differed from routine formula by how much?

A

-9 to +19%

69
Q

what is eBAT?

A

bispecific angiotoxin of pseudomonas exotoxin fused with EGF and uPAR

70
Q

what was 6mn ST in eBAT vs SOC dogs?

A

70% vs 38%

71
Q

what human cancer expresses uPAR and EGFR?

A

pediatric sarcoma

72
Q

what is MOA of iniparib?

A

PARP inhibitor

73
Q

what is KPT-335?

A

SINE inhibitor

74
Q

what is MTD of KPT-335?

A

1.75mg/kg twice weekly (later study used 1.5mg/kg)

75
Q

what is DLT of KPT-335?

A

hepatotox, anorexia, weight loss

76
Q

what is impact of repeated cycles of eBAT in HSA?

A

increased AE and no benefit vs SOC

77
Q

What is utility of FDG PET CT for HSA in dogs?

A

2/9 dogs had lesions not noted on CXR/AUS

78
Q

what is ORR of KPT-335 and response in T cells?

A

ORR 37%

T cell ORR 71%

79
Q

what is valspodar?

A

selective inhibitor of ATP binding cassette B1 transporter (ABCB1)

80
Q

what was impact of valspodar on lymphoid progenitor cells (CD34+, CD117+, CD133+)?

A

no difference, although safe

81
Q

What was efficacy of salmonella encoding IL2 combination w/ amputation and dox for OSA?

A

Longer DFI vs dox alone but not vs carbo/dox

82
Q

What is RR in gross dz setting to 5-FU/carboplatin in dogs?

A

43%

83
Q

what is most common AE with 5-FU/carbo in dogs?

A

myelosuppression (plt > neut) and one episode ataxia

84
Q

what MOA do 6-TG and Zebularine share?

A

DMNT 1 inhibitors

85
Q

Does SQ administration of excipient free nanoparticle paclitaxel have systemic absorption?

A

no - so may be good intratumoral drug

86
Q

what is MTD of excipient free nanoparticle paclitaxel?

A

unknown - doses used 80-136mg/m2 SQ and IV

87
Q

what PK model fits hyaluronan-cisplatin nanoconjugate?

A

3 compartment

88
Q

what cancer type had CR to hyaluronan-cisplatin nanoconjugate?

A

nasal and oral SCC

89
Q

what is MC AE with hyaluronan-cisplatin nanoconjugate?

A

40% myelosuppression, 12% cardiotox

90
Q

T/F Papillomavirus is a causative agent of canine orbital adenomas

A

false

oncology boards (4 decks)

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