Specific Transdermal Products Flashcards
what products are available for transdermal testosterone?
testoderm and androderm (brand names)
between testoderm and androderm - determine which is membrane and which is matrix type
matrix type = testoderm
membrane type = androderm
explain in detail the components of testoderm
matrix type 3-layer patch
-backing layer of PET
-matrix film layer of testosterone
-adhesive strips of polyisobutylene, colloidal silicone dioxide
differentiate between where the patch is placed between androderm and testoderm
testoderm - patch is placed on scrotum to treat testosterone deficiency (DONT NEED PERMEATION ENHANCER)
androderm - patch is placed on back, abdomen, upper arms, or thighs – MAINLY CHEST (NEED PERMEATION ENHANCER)
Explain in detail the contents of androderm patch
five layer, membrane type patch
-backing film of ethylene-vinyl acetate copolymer, polyester laminate
-reservoir of testosterone, alcohol, glycerin, glyceryl monooleate, methyl laurate felled with acrylic acid copolymer
-microporous polyethylene membrane
-acrylic adhesive
-adhesive polyester laminate
name the transdermal products that are for PREVENTION and not treatment
transdermal nitroglycerin and transdermal scopolamine
what is the brand name for transdermal scopolamine
Transderm Scop
is Transderm Scop membrane or matrix type
membrane
explain how Transderm Scop is used
there is continuous release of the drug over THREE DAYS to PREVENT nausea and vomiting from motion sickness
the patch is placed behind the ear
for repeated administration, the first patch is removed and 2nd patch placed behind the other ear
also approved to PREVENT nausea of certain anashetics/analgesics used in surgery
explain the design of transderm scop
4 layer, membrane type patch
-backing layer of aluminized polyester film
-reservoir of scopolamine, mineral oil, polyisobutylene
-microporous polypropylene membrane (for rate control)
-adhesive of polyisobutylene, mineral oil, scopolamine
true or false
scopolamine is for the treatment of nausea and vomiting due to motion sickness
FALSE - for prevention, not treatment
what are the brand name products of transdermal nitroglycerin
deponit
nitro-dur
transderm-nitro
state the 3 transdermal nitroglycerin products and whether they are membrane or matrix type
Deponit - matrix
Nitro-dur - matrix
transderm-nitro - membrane type
explain the design of Deponit
three layer, matrix type system
-covering foil (ensure unidirection)
-nitroglycerin matrix with adhesive, plasticizer
-protective foil (removed before use)
what is the function of a plasticizer
increases surface area so polymer can spread
used in Deponit in 2nd layer
explain the design of Nitro-Dur
5-layer, matrix type patch
nitroglycerin in gel-like matrix of glycerin water, lactose, PVA, povidone, sodium citrate sealed in polyester, foil, polyethylene laminate
explain the contents of transderm-nitro
4-layer, membrane type system
-backing layer
-reservoir of nitroglycerin
-ethylene-vinyl acetate copolymer membrane
-silicone adhesive
transdermal nitroglycerin is a _____ hour patch
24
what is the brand name for transdermal clonidine
Catapres-TSS (clonidine transdermal therapeutic system)
is catapres-TTS matrix or membrane type? how many layers is it? what is the generic?
generic = transdermal clonidine
membrane type
4 layers
explain the design of Catapres-TTS
-backing of pigmented polyester film
-reservoir of clonidine
-microporous polypropylene membrane
-adhesive
explain how Catapres-TTS is applied and what it’s used for
antihypertensive – delivered at a constant rate for 7 DAYS
generally applied to hairless or shaven area of the UPPER ARM or TORSO
explain the lack of control that exists with Catapres-TTS
not that easy to control because the delivery is over 7 days and we can’t really control the day by day release
of the transdermal patches mentioned in this chapter, which 3 are most popular
scopolamine
nitroglycerin
nicotine
name a transdermal patch that is not used for treatment (but not prevention really either)
NICOTINE
name all the brand names of transdermal nicotine
Habitrol
NicoDerm
Nicotrol
Prostep
determine whether all the brand names of transdermal nicotine are matrix or membrane type
Habitrol - matrix
Nicotrol - matrix
Prostep - matrix
Nicoderm - membrane
between all the brand names of transdermal nicotine, which are round patches and which are rectangular?
round - Habitrol, prostep
rectangle - nicoderm, nicotrol
who manufactures nicoderm and nicotrol?
GSK
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name the brand names of transdermal estradiol
Estraderm
Vivelle
Climara
name the brand names of transdermal estradiol and state whether they are membrane or matrix type
membrane - Estraderm
matrix - Vivelle, Climara
explain how estraderm is applied
releases 17Beta estradiol continuously, patch is applied to trunk (including abdomen and buttocks) at ALTERNATING SITES, TWICE WEEKLY OVER A 3 WEEK CYCLE with dosage frequency being adjusted as required
explain how Vivelle is used
same as estroderm
explain how Climara is used
similar to Estroderm, but the system may be applied WEEKLY instead of twice weekly over a 3 day period
of the brand transdermal estradiols, name the # of layers in each
estraderm - 4 layer
vivelle - 3 layer
climara - 3 layer
of the brand transdermal estradiol, which contain(s) a separate adhesive layer?
Estraderm is the only one
other 2 (vivelle and climara) have adhesive contained in the matrix
what is the component of the rate controlling membrane that is frequently used in transdermal patches?
EVA (ethylene-vinyl acetate copolymer membrane)
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what is the brand name for transdermal fentanyl
Duragesic
is Duragesic membrane or matrix type
membrane
as a general rule, which usually require a separate adhesive layer - membrane or matrix type?
membrane
explain how long Duragesic can be used and why it is used
continuous 72 hour SYSTEMIC delivery of potent opioid analgesic (10x more potent than morphine) in pts with chronic pain requiring opioids
what is the onset time of Duragesic
VERY FAST
the silicone adhesive contains fentanyl which allows for immediate release for those with extreme pain
explain the components of Duragesic
4-layer, membrane type system
-backing layer of polyester film
-reservoir of fentanyl, alcohol gelled with hydroxyethyl cellulose
-rate controlling ethylene-vinyl acetate copolymer membrane
-fentanyl containing silicone adhesive
