SPECIFIC SKIN MANIFESTATIONS IN RENAL DISEASE

Question 1

What are the 6 SPECIFIC SKIN MANIFESTATIONS IN RENAL DISEASE?

Answer 1

1. NEPHROGENIC SYSTEMIC FIBROSIS
2. METASTATIC RENAL CELL CA
3. DIALYSIS-ASSOCIATED STEAL SYNDROME
4. DIALYSIS-RELATED AMYLOIDOSIS
5. AV SHUNT DERMATITIS
6. UREMIC FROST

Question 2

What is the result after exposure to gadolinium-based magnetic resonance imaging (MRI) contrast agents in patients with abnormal renal function?

Answer 2

NEPHROGENIC SYTEMIC FIBROSIS

Question 3

Caution in using gadolinium is recommended in these 3 subsets of pxs

Answer 3

1. EGFR < 30
2. CKD on HD
3. AKI

Question 4

What are the clinical manifestations of NSF?

Answer 4

SKIN:
• bound-down, indurated skin on the extremities
• cobblestone appearance
• edema and erythema that mimics cellulitis (early in the disease process)

JOINT:
• contractures

SCLERA:
• yellow scleral plaques

Question 5

What are the 4 risk factors predisposing to Dialysis-associated steal syndrome?

Answer 5

1. diabetes
2. vascular stenosis
3. neuropathic disease
4. calcifying sclerosis

Question 6

What is the disease which histologic findings of a tumor with clear cells and prominent hemorrhage?

Answer 6

von Hippel–Lindau (VHL)-deficient clear cell renal cell carcinoma

Question 7

Dialysis-related amyloidosis is secondary to what type of deposition?

Answer 7

β2-microglobulin

Question 8

What are the 2 more common presentations of Dialysis-related amyloidosis?

Answer 8

1. carpal tunnel syndrome
2. destructive arthropathy