SOMEWHAT SPECIFIC SKIN MANIFESTATIONS SECONDARY TO RENAL DISEASE Flashcards
What are the 6 SOMEWHAT SPECIFIC skin manifestations associated with renal disease?
- ACQUIRED PERFORATING DERMATOSIS
- BLISTERING DISORDERS
- CALCIPHYLAXIS
- METASTATIC CALCIFICATION
- ERUPTIVE XANTHOMAS
- PSEUDO-KAPOSI SARCOMA
What are the 2 blistering disorders in renal disease?
- PORPHYRIA CUTANEA TARDA
- PSEUDOPORPHYRIA
What disorder is considered as variant of prurigo nodularis?
ACQUIRED PERFORATING DERMATOSIS
What is the skin disorder wherein Individual lesions are crateriform, umbilicated, or centrally hyperkeratotic papules and nodules?
ACQUIRED PERFORATING DERMATOSIS
How many weeks does lesions in acquired perforating necrosis resolve with scarring?
6-8 weeks
What 3 diseases is associated with Acquired perfoating dermatosis?
- DM
- HEP B
- HYPOTHYROIDISM
What are the 4 treatments for acquired perforating dermatosis?
- STEROIDS (TOPICAL)
- RETINOIDS (ORAL/IV)
- LUBRICATION
- KERATOLYTICS
Calciphylaxis is also known as?
CALCIFIC UREMIC ARTERIOLOPATHY
What skin disorder is seen in patients with ESRD who are on HD with associated hyperparathyroidism or an elevated calcium phosphate product?
CALCIPHYLAXIS
Involvement of what 2 parts of the body is associated with high mortality?
- TRUNK
- BUTTOCKS
What are the 14 risk factors for calciphylaxis?
- FEMALE
- OBESITY
- RAPID WEIGHT LOSS
- DM
- MALIGNANCY
- LIVER CIRRHOSIS
- INFECTION
- SYSTEMIC INFLAMMATION
- HYPOALBUMINEMIA
- PROTEIN C,S DEFICIENCY
- SYSTEMIC STEROID USE
12.WARFARIN USE - IRON USE
- CHEMOTHERAPY
What 3 fatty areas of the body is symmetrically affected in calciphylaxis
- ABDOMEN
- THIGHS
- BUTTOCKS
What are the histopathologic findings in calciphylaxis?
medial calcification of medium-sized vessels with intimal hyperplasia and thrombosis
What is a somewhat specific skin manifestation wherein lesions are hard, yellow to bluish papules and nodules, which usually affect periarticular areas and the fingertips?
METASTATIC CALCIFICATION
Trauma may cause what type of calcification?
DYSTROPHIC CALCIFICATION
What somewhat specific skin manifestation which results from deficient activity of the heme biosynthetic enzyme uroporphyrinogen decarboxylase (UROD) in the liver?
PORPHYRIA CUTANEA TARDA
What compound is elevated in the urine of patients with prophyria cutanea tarda?
URINARY UROPORPHYRIN
What compound is elevated in the feces of patients with prophyria cutanea tarda?
FECAL ISOCOPROPORPHYRIN
What are the risk factors for developing porphyria cutanea tarda?
- UROD DEFICIENCY
- HBV
- HCV
- HIV
- ESTROGEN USE
- ALCOHOL INTAKE (EXCESSIVE)
Cutaneous findings in porphyria cutanea tarda which include noninflamed blisters, erosions, and crusts involve which 2 parts of the body?
- DORSAL HANDS
- FOREARMS
IF findings in porphyria cutanea tarda include granular to linear staining of these 2?
• IgG
• C3
Concomittant use of these 5 drugs are involved in the development of pseudoporphyria
- FUROSEMIDE
- AMIODARONE
- NALIDIXIC ACID
- TETRACYCLINE
- NAPROXEN
What are the yellow-orange smooth papules and plaques which on histopathologic examination of a lesion reveals extracellular lipid and foamy macrophages?
ERUPTIVE XANTHOMA
What are the translucent papulonodular or vegetative lesions that develops after patient with renal insufficiency receive iodide in the form of IV contrast?
IODODERMA
