SOMEWHAT SPECIFIC SKIN MANIFESTATIONS SECONDARY TO RENAL DISEASE

Question 1

What are the 6 SOMEWHAT SPECIFIC skin manifestations associated with renal disease?

Answer 1

1. ACQUIRED PERFORATING DERMATOSIS
2. BLISTERING DISORDERS
3. CALCIPHYLAXIS
4. METASTATIC CALCIFICATION
5. ERUPTIVE XANTHOMAS
6. PSEUDO-KAPOSI SARCOMA

Question 2

What are the 2 blistering disorders in renal disease?

Answer 2

1. PORPHYRIA CUTANEA TARDA
2. PSEUDOPORPHYRIA

Question 3

What disorder is considered as variant of prurigo nodularis?

Answer 3

ACQUIRED PERFORATING DERMATOSIS

Question 4

What is the skin disorder wherein Individual lesions are crateriform, umbilicated, or centrally hyperkeratotic papules and nodules?

Answer 4

ACQUIRED PERFORATING DERMATOSIS

Question 5

How many weeks does lesions in acquired perforating necrosis resolve with scarring?

Answer 5

6-8 weeks

Question 6

What 3 diseases is associated with Acquired perfoating dermatosis?

Answer 6

1. DM
2. HEP B
3. HYPOTHYROIDISM

Question 7

What are the 4 treatments for acquired perforating dermatosis?

Answer 7

1. STEROIDS (TOPICAL)
2. RETINOIDS (ORAL/IV)
3. LUBRICATION
4. KERATOLYTICS

Question 8

Calciphylaxis is also known as?

Answer 8

CALCIFIC UREMIC ARTERIOLOPATHY

Question 9

What skin disorder is seen in patients with ESRD who are on HD with associated hyperparathyroidism or an elevated calcium phosphate product?

Answer 9

CALCIPHYLAXIS

Question 10

Involvement of what 2 parts of the body is associated with high mortality?

Answer 10

1. TRUNK
2. BUTTOCKS

Question 11

What are the 14 risk factors for calciphylaxis?

Answer 11

1. FEMALE
2. OBESITY
3. RAPID WEIGHT LOSS
4. DM
5. MALIGNANCY
6. LIVER CIRRHOSIS
7. INFECTION
8. SYSTEMIC INFLAMMATION
9. HYPOALBUMINEMIA
10. PROTEIN C,S DEFICIENCY
11. SYSTEMIC STEROID USE
    12.WARFARIN USE
12. IRON USE
13. CHEMOTHERAPY

Question 12

What 3 fatty areas of the body is symmetrically affected in calciphylaxis

Answer 13

1. ABDOMEN
2. THIGHS
3. BUTTOCKS

Question 14

What are the histopathologic findings in calciphylaxis?

Answer 14

medial calcification of medium-sized vessels with intimal hyperplasia and thrombosis

Question 15

What is a somewhat specific skin manifestation wherein lesions are hard, yellow to bluish papules and nodules, which usually affect periarticular areas and the fingertips?

Answer 15

METASTATIC CALCIFICATION

Question 16

Trauma may cause what type of calcification?

Answer 16

DYSTROPHIC CALCIFICATION

Question 17

What somewhat specific skin manifestation which results from deficient activity of the heme biosynthetic enzyme uroporphyrinogen decarboxylase (UROD) in the liver?

Answer 17

PORPHYRIA CUTANEA TARDA

Question 18

What compound is elevated in the urine of patients with prophyria cutanea tarda?

Answer 18

URINARY UROPORPHYRIN

Question 19

What compound is elevated in the feces of patients with prophyria cutanea tarda?

Answer 19

FECAL ISOCOPROPORPHYRIN

Question 20

What are the risk factors for developing porphyria cutanea tarda?

Answer 20

1. UROD DEFICIENCY
2. HBV
3. HCV
4. HIV
5. ESTROGEN USE
6. ALCOHOL INTAKE (EXCESSIVE)

Question 21

Cutaneous findings in porphyria cutanea tarda which include noninflamed blisters, erosions, and crusts involve which 2 parts of the body?

Answer 21

1. DORSAL HANDS
2. FOREARMS

Question 22

IF findings in porphyria cutanea tarda include granular to linear staining of these 2?

Answer 22

• IgG
• C3

Question 23

Concomittant use of these 5 drugs are involved in the development of pseudoporphyria

Answer 23

1. FUROSEMIDE
2. AMIODARONE
3. NALIDIXIC ACID
4. TETRACYCLINE
5. NAPROXEN

Question 24

What are the yellow-orange smooth papules and plaques which on histopathologic examination of a lesion reveals extracellular lipid and foamy macrophages?

Answer 24

ERUPTIVE XANTHOMA

Question 25

What are the translucent papulonodular or vegetative lesions that develops after patient with renal insufficiency receive iodide in the form of IV contrast?

Answer 25

IODODERMA