Specific Immunity Flashcards
Function of T lymphocytes?
cellular immune response and regulation of B lymphocytes and macrophages
What percentage of all leukocytes do eosiinophils comprise?
1-6%
When B cells encounter antigen, they differentiate into ____ and produce _____.
plasma cells; antibodies
What percentage of WBCs do neutrophils comprise?
40-75%
Cytotoxic T cells have which type of co-receptor?
CD8
What is the first step in the complement cascade that combines the two pathways?
C3 activation
What cytokine stimulates the growth of helper T and NK cells?
IL-2
Monocytes comprise what percent of all leukocytes?
2-10%
T-cell glycoproteins: What is the CD3 complex?
a cluster of polypeptides associated with a T-cell receptor. It is important in signal transduction
Which Ig isotype is found in secretions?
IgA
Which major cytokines re produced by macrophages? (3)
IL-1, IL-6, and TNF-alpha
Name two markers present on T helper cells.
CD3, CD4
What influence doe gamma interferon have on MHCI and II?
upregulates MHCI and II in all cells.
What do TNF-alpha and TNF-beta do? (3)
increase IL-2 output and B-cell proliferation, attract neutrophils
The amino terminal is part of which fragment of the antibody?
fab fragment
Where do B-lymphocytes mature?
bone marrow (B= bone marrow)
What is secreted in the granules of a basophil? (2)
heparin (anticoagulant), histamine (vasodilator), other vasoactive amines
Which cytokines promote the growth and differentiation of B cells? (3)
IL-4, IL-5, TNF-alpha
What recognizes endogenously synthesized (viral or self) proteins that are presented by MHC I?
TCR on cytotoxic T cell
In the tissues, monocytes differentiate into which cells?
macrophages
CD4 cell secretes which growth factor to activate the CD8 cells?
IL-2
Which Ig isotype guards the mucous membranes from attachment of bacteria and viruses?
IgA
Name two markers present on cytotoxic T cells.
CD3, CD8
The classic pathway is initiated by which Ig isotypes?
IgM or IgG