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NPLEX - Micro/Immuno > Obligate intracellular bacteria > Flashcards

Obligate intracellular bacteria Flashcards

1
Q

What are the clinical manifestations of Chlamydia trachomatis? (6)

A

urethritis; cervicitis; salpingitis (PID); Inclusion Conjunctivitis; Lymphogranuloma venerum: Trachoma.

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2
Q

Where is rocky mountain spotted fever common?

A

endemic to the east coast

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3
Q

What are the clnical manifestations of Chlamydia pneumoniae? (3)

A

walking pneumonia in young adults, pharyngitis, bronchitis

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4
Q

What serotypes of Chlamydia trachomatis cause lymphogranuloma venereum?

A

L1-L3

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5
Q

How is Chlamydia pneumoniae transmitted?

A

respiratory droplets

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6
Q

How is Chlamydia trachomatis transmitted?

A

close, intimate contact, human to human

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7
Q

Rocky Mountain spotted fever; What are the symptoms of Rocky Mountain spotted fever? What is the causative agent?

A

classic triad of reckettsial disease-headache, fever, rash. Reckettsia rickeettsii

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8
Q

T/F: Ricketsia are facultative intracellular parasites

A

False, they are obligate parasites

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9
Q

What are the clinical manifestations of Rickettsia typhi?

A

murine typhus-a milder form of typhoid fever

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10
Q

What are the clnical manifestations of Chlamydia psittaci? (5)

A

psittacosis. After 1-3 week incubation, flu like syndrome with fever and chills. Progressive cough. 30% mortality if untreated. Complications include myocarditis, encephalitis, hepatitis.

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11
Q

What is the reservoir of Chlamydia psittaci?

A

has an avian reservoir

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12
Q

What is the morphology of Chlamydia psittaci?

A

obligate intracellular bacteria

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13
Q

Most Ricketsia are transmitted by what?

A

arthropod vector

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14
Q

Rocky Mountain spotted fever; What three diseases have characteristic palm and sole rash?

A

rocky Mountain spotted fever, syphilis and coxsackievirus A16 (hand, foot, and mouth disease)

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15
Q

What is the classic triad of rickettsial infection? (3)

A

headache, fever, rash

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16
Q

What are the top organisms that cause PID? (2)

A

Chlamydia trachomatis (subacute, often undiagnosed), Neiseria gonorrheae (acute, high fever)

17
Q

How is Chlamydia psittaci transmitted?

A

inhalation of dried bird feces. Also air droplets, person to person

18
Q

What is the major reservoir for Rickettsia rickettsii?

A

deer and other wild animals

19
Q

Identify relevant epidemiology and risk factors associated with Rickettsia typhi

A

attacks only one or a few people at once (compare R. prowazecki)

20
Q

Rickettsial diseases and vectors: What bug causes Epidemic typhus? What is the vector?

A

rickettsia prowazeckii. Human body louse.

21
Q

HOw does the rash of Rocky Mountain spotted fever progress?

A

centripetally, starting on palms and soles, migrating to wrists/ankles, then trunk.

22
Q

What are the clinical manifestations of Rickettsia rickettsii?

A

rocky mountain spotted fever-3-12 days incubation, acute onset of fever, severe headache, prostration and myalgia. 2-6 days later, macules, petichiae start on hands and feet, then move to trunk. DIC edema and circulatory collapse can occur in severe cases.

23
Q

What lab findings are useful to help diagnose Chlamydia psittaci? (2)

A

cytoplasmic inclusion bodies inside epithelial cells; CXR shows patchy infiltrates radiating from the hilum.

24
Q

What is the most common associated with Chlamydia trachomatis?

A

most common STD in the United States (3-4 million cases per year)

25
Q

How is neonatal chlamydia acquired?

A

passage through infected birth canal

26
Q

Identify relevant epidemiology and risk factors associated with Rickettsia rickettsii.

A

eastern United States. May to September.

27
Q

How is Rickettsia typhi transmitted?

A

flea bites

28
Q

How is Rickettsia rickettsii transmitted?

A

bite of the deer-tick

29
Q

Rickettsial diseases an dvectors: what bug causes Endemic typhus? What is the vector?

A

rickettsia typhi, flea vector

30
Q

What is the morphology of Chlamydia pneumoniae?

A

obligate intracellular bacteria

31
Q

What is the morphology of Rickettsia rickettsii?

A

obligate intracellular bacteria

32
Q

Why do obligate intracellular bacteria need a host cell?

A

they cannot make ATP

33
Q

What is the major reservoir for Rickettsia typhi?

A

wild rodents, rats especially

34
Q

Lymphogranuloma vereum is caused by what organism?

A

chlamydia trachomatis

35
Q

Rickettsial diseases and vectors: What bug causes Rocky Mountain spotted fever? What is the vector?

A

rickettsi reckettsii, tick vector

36
Q

What serotypes of Chlamydia trachomatis cause chlamydia?

NPLEX - Micro/Immuno (18 decks)

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