Immune dysfunction Flashcards
What is the mechanism of a type III hypersensitivity reaction?
soluble antibody-antigen complexes activate complement and attract inflammatory cells.
What are some examples of conditions caused by type III hypersensitivity reactions? (3)
SLE, rheumatoid arthritis, serum sickness
What Ig isotypes are common in a type II hypersensitivity reaction? (2)
IgM and IgG
What are some examples of type I hypersensitivity reactions? (4)
anaphylactic shock, asthma, hives, local wheal and flare reactions
What happens in a type II hypersensitivity reaction?
antibodies bind to a perceived foreign cell and use complement and phagocytosis to kill it.
What is the mechanism of a type IV hypersensitivity reaction?
T-cell mediated and therefore delayed
What is another name for type I hypersensitivity?
anaphylactic or atopic
What is a serum sickness?
a type III reaction to a foreign protein such as an injected drug. It takes about 5-10 days to resolve in most cases and presents with fever, utricara, arthralgia, and proteinuria.
What are some examples of conditions caused by type II hypersensitivity reactions? (4)
goodpastures, autoimmune hemolytic anemia, graves disease and rheumatic fever
What is another name for type II hypersensitivity?
cytotoxic
What are examples of type IV hypersensitivity reactions? (3)
TB skin test, poison ivy, transplant rejection
What do type I, II and III hypersensitivity reactions have in common?
they all use antibodies
Which cells are involved in type I hypersensitivity? (2)
mast cells and basophils
What Ig triggers type I hypersensitivity reactions?
IgE
