Special Path Liver Neoplasms Flashcards
Hepatocellular carcinomas are often ___ and occupy _____.
Often single and occupy an entire liver lobe
What is expected in the liver over all and hepatocytes in hepatocellular carcinomas?
Loss of liver architecture and morphological changes in hepatocytes
Are hepatocellular carinomas metastatic?
May or may not
Which ones are more common: hepatocellular carcinomas or adenomas?
carcinomas
CASE: large tumors on liver, blood in abdomen when tumor ruptures (indicates acute); histo section shows hepatic cords are many more cell thick and poorly organized compared to normal liver
Hepatocellular carcinoma
Hepatocellular adenomas
Tend to be single, rounded, lobated or pedunculated and cells closely resemble normal hepatocytes, microscopically.
What is the main difference microscopically between hepatocellular adenomas and carcinomas?
In carcinomas, hepatocytes morphologically change. In adenomas, hepatocytes resmble normal hepatocytes.
Hepatic nodular hyperplasia is common in what age of dogs?
Older dogs
Hepatic nodular hyperplasia contains all the elements of a normal lobule, but creates a ____ pattern.
Distorted
It is important to be able to distinguish hepatic nodular hyperplasia from neoplasms. How does hepatic nodular hyperplasia present itself grossly?
Multiple nodules; compress adjacent liver; raised, yellow to tan (.5-3.0cm)
Cholangiocellular adenoma are adenomas of _____.
Bile ducts
Cholangiocellular adenomas are more common in what species and what age?
Older cats
Gross lesions of cholangiocellular adenoma:
firm gray - white masses composed of well differentiated bile duct epithelium
Cholangiocellular carcinomas are_____.
Malignant neoplasms of biliary epithelium.
Cholangiocellular carcinomas occur in what species?
All
