Sorbitol Flashcards
1
Q
Glucose can be converted to sorbitol via the enzyme:
A
aldose redutase
2
Q
Sorbitol is the _____________ of glucose
A
Alcohol counterpart
3
Q
What can convert sorbitol to fructose?
A
Sorbitol dehydrogenase
4
Q
Sorbitol that converts to fructose can then enter which pathway? How?
A
Glycolysis
Fructose converted to fructose 1-phosphate –>glyceraldehyde
5
Q
Examples of tissue that LACK sorbitol dehydrogenase:
A
Lens, retina, and Schwann cells
6
Q
Sorbitol does what to cells? Why?
A
Draws water in - osmotically active
7
Q
Sorbitol can damage the lens, retina, and nerves because it is osmotically active. This causes what?
A
Premature cataracts
Retinopathy
Peripheral neuropathy
