Solutions & Suspensions (lecture 3)

Question 1

Solutions

Answer 1

Most rapid absorption of oral dosage forms

Question 2

• Suspensions

Answer 2

Solid particles suspended in a liquid
Liquid has dissolved drug plus excipients such as surfactants which are also suspending agents
Still require dissolution even though a liquid dosage form. Formulation considerations include particle size, viscosity, and wetting agents.
“Shake Well”

Question 3

Limitations/challenges

Answer 3

Liquid dosage forms have limitations
Poor water solubility of drug
Poor chemical stability
– Most common degradation is hydrolysis of organic acid derivatives.
Sterility requirements Compatibility with biological fluids