capsules hard soft (lecture 3)

Question 1

Capsules

Answer 1

• Soliddosageformwithapolymericshell(hardor soft) that should quickly release drug.
• Polymericshell:Gelatinisdegradedinthegutby proteolytic enzymes
• Polymericshell: Hydroxypropylmethylcellulose (HPMC )
  
  • vegetarian version of gelatin

Question 2

Hard Gelatin Capsules

Answer 2

– Locking cap and body containing the drug substance.
– Alternative to tablets, easier to swallow, and can be used
to deliver powders, granules, beads, and liquids.
– Gelatin is a protein obtained by partial hydrolysis of collagen derived from bovine or porcine skin and bones.

Question 3

Hard Gelatin Capsules

Answer 3

• Ingredients(Composition:

• Gelatin
• Plasticizers
• Preservatives
• Colorants & opacifiers

Question 4

fill capacity

Answer 4

larger the capsule size the less volume to fill

000-1.37
00- .95
0-.68
1- .50
.
.
.
.
5- .13

Question 5

advantages of hard gelatin

Answer 5

• capsule dissolves faster than tablets
• there is no need to form a hard compact
• power, beads, granules, and even liquids can be filled
• they are easy to swallow
• thy can be sued for blinding studies

Question 6

disadvantages of hard gelatin

Answer 6

• capsule filling in slow compared to tableting
• stability could be a problem
• there are concerns related to bovine spongiform encephalopathy

Question 7

Soft gelatin capsules

Answer 7

Soft Gelatin Capsules

• Has higher plasticizer content (softness and flexibility).
• Can be used to improve bioavailability, since a suspension or solution can be encapsulated inside
• High patient compliance & tamper evident properties.

Question 8

Hard gelatin

Answer 8

•Hard gelatin

• The Body vs the cap
• Ridges and dimples for mechanical interlocking between the body and the cap

Question 9

Soft gelatin

Answer 9

Soft gelatin
used for liquicaps containing a liquid formulation or semisolid One-unit capsules
Hermetically sealed (not sealed by mechanical interlocking) Has water content
Opacifier
Has plasticizer (glycerin or sorbitol)