Solubility and Distribution Flashcards
Intrinsic
Altered only by chemical modification
Solubility
Extrinsic
Influenced by chemical, physical, or crystallographic means
Dissolution
Very Soluble (parts of solvent for one part of solute)
<1
The rate at which a molecule moves through a material is proportional to the concentration gradient, inversely proportional to the thickness of the membrane
Fick’s Law of Diffusion
Smaller particle size equates to
greater surface area and faster rate of dissolution
strong dipole effect and hydrogen bonding property; charges are separated permanently
polar solvents
strong dipole but do not have strong h-bonding activity
semipolar solvents
induce degree of polarity in a nonpolar solvent
semipolar solvents
It indicates the effect that a
substance has, when it acts as a medium, on the ease with
which two oppositely charged ions may be separated.
dielectric constant
epsilon = >50
polar solvents
epsilon = 20 - 50
semi - polar solvents
epsilon = 1 - 20
non - polar solvents
refers to the mutual solubilities of the components in a liquid-liquid system
miscibility
partial miscibility is affected by
temperature
substance is more soluble in higher temperatures
endothermic