Solitions-Buffers

Question 1

When the pH is changed, the ratio of the ionized from and the non-ionized form changes, resulting in a change in the apparent total ______

Answer 1

Solubility

Question 2

Buffer

Answer 2

Compound or mixture of compounds that when present in solution resists changes in the pH of the solution when small quantities of acid or base are added to the solution

Question 3

What is the purpose of buffers

Answer 3

Gain solubility advantage
Render product more compatible with tissue
Enhance product stability
Influence product absorption

Question 4

Acetate buffer system

Answer 4

Acetic acid and sodium acetate
Good for low to mid pH
Good for systemic, topical, ophthalmic preparations

Question 5

Citrate Buffer

Answer 5

Citric acid and trisodium citrate
Low to mid pH
Systematic, topical, ophthalmic

Question 6

Phosphate buffer

Answer 6

Monobasic and dibasic sodium phosphate
Alkaline pH

Question 7

Borate buffer

Answer 7

Boric acid and sodium borate
Mildly alkaline pH