Solid Organ Transplantation: Organ Specific Considerations

Question 1

True or false: Adaptive immunity occurs rapidly, is antigen specific and has cellular memory

Answer 1

False. Slow (1-2 weeks), antigen specific and has cellular memory

Question 2

T-lymphocytes are produced in the _____ ________ and mature in the ________

Answer 2

Bone marrow. Thymus.

Question 3

What is the complement system responsible for?

Answer 3

Opsonization, Inflammation, Lysis

Question 4

Sensitized patients have a panel of reactive antibodies (PRA) > ___ %

Answer 4

20%

Question 5

What is the difference between preformed and de novo donor specific antibodies (DSA) forming?

Answer 5

Preformed: identified before transplant and increased chance for early rejection and graft loss
de novo: developed after transplant and associated with late and chronic rejection

Question 6

Why is immunosuppression necessary for solid
organ transplantation?
1. To protect the recipient from donor immunologic cells
that came with the organ
2. To protect the allograft (donor organ) from the
recipient’s immune system
3. Precautionary until the recipient becomes tolerant to
the allograft
4. Immunosuppression is voodoo medicine, we really do
not need it

Answer 6

2. To protect the allograft (donor organ) from the
   recipient’s immune system