Sickle Cell Disease, Aplastic and Hemolytic Anemia

Question 1

Clinical features of sickle cell disease

Answer 1

. Pain
. Fatigue and pallor
. Weakness
. Swelling of extremities
. Gallstones
. Leg ulcers
. Anemia
. Hematuria

Question 2

Immunizations recommended in sickle cell disease

Answer 2

. Influenza
. COVID-19
. Pneumococcal
. Meningococcal

Question 3

Which antimicrobial agent is recommended for pneumococcal prophylaxis in sickle cell? Alternative for intolerance to first line agent?

Answer 3

Penicillin VK
Erythromycin alternative

Question 4

First line agent recommended for treatment of sickle cell disease?

Answer 4

Hydroxyurea