Solid Organ Transplant - Med Chem

Question 1

Which organ is the most commonly transplanted?

Answer 1

Kidney

Question 2

What are the three stages of immunosuppression?

Answer 2

Induction, Maintenance, Rejection

Question 3

Which induction phase is characterized by high dose, short duration IV therapy with the goal of preventing hyperacute and acute rejection?

Answer 3

Induction

Question 4

Difference between non-lymphocyte depleting and lymphocyte depleting agents?

Question 5

Non-lymphocyte depleting agent examples

Answer 5

. Corticosteroids
. IL-2 receptor antagonists: Basiliximab

Question 6

Lymphocyte depleting agent examples

Answer 6

. Anti-thymocyte globulin
. Alemtuzumab (Campath)

Question 7

True or false: Alemtuzumab requires pre-medication with diphenhydramine, acetaminophen and steroids

Answer 7

False. One time intraoperative dose, does not require pre-medication. May use pre-medication regimen for thymoglobulin administration.

Question 8

True or false: Basiliximab does not require monitoring.

Answer 8

True. It is non-lymphocyte depleting and mainly has GI adverse effects

Question 9

Prednisone to methylprednisolone conversion factor

Answer 9

5mg prednisone = 4mg methylprednisolone

Question 10

Which cyclosporine formulation is unmodified?
a. Neoral
b. Sandimmune
c. Gengraf

Answer 10

b. Sandimmune. Oil based, vs. modified cyclosporine which is a modified microemulsion and has more predictable absorption

Question 11

What would be an appropriate dose of sublingual tacrolimus if a patient was admitted to the ICU (now intubated) and was stable on Prograf 3 mg BID prior to admission?
a. 3 mg SL BID
b. 1.5 mg SL BID
c. 3 mg SL daily
d. 1.5 mg SL daily

Answer 11

b. 1.5 mg SL BID