solid oral dosage forms Flashcards
what are tablets?
they are solid preparations containing a single dose of one or more drugs.
- they are compressed uniform volumes of powders
- usually for oral use
- amount of drug is usually in mg or mcg
what are the different types of tablets?
caplets, dispersible/soluble, effervescent, buccal, sublingual, chewable, orodispersible, modified release, coated tablets
what are some reasons for coating?
protect the drug, mask taste/appearance, identification, easier to swallow, changing release properties
what are the types of polymers
film - polymers, sugar (s/c) - sucrose
what are capsules?
one or more drugs encased in a gelatin shell
do capsules have to be swallowed?
they can be swallowed whole or opened
what are the 2 types of capsuleS?
hard gelatin and soft gelatin
are powders for internal or external use?
powders can be for internal or external use
are granules for internal or external use?
for internal use
what are the 3 types of modified release?
- delayed release (Releases drug after a specific time frame to help target drug delivery)
- enteric coating (pH dependant release)
- extended release
what does enteric coating do?
prevents release of drug in the stomach
what are the advantages of tablets and capsules?
very stable, accurate dosing, convenient for patient, easy to make and low cost, taste can be masked, release can be modified, can be enteric coated
what are the disadvantages of tablets and capsules
slow onset of action, 1st pass metabolism, systemic action and side effects, gelatin issues, difficulty swallowing
what are the advantages of powders and granules
very stable and can be reconstituted to liquids, accurate dosing from sachets, faster onset of action, good for patients with difficulty swallowing, release can be modified for granules, good for large doses
what are the disadvantages of powders and granules
less convenient for patient, inaccurate dosing from bulk pots, 1st pass metabolism, systemic action and side effects, difficult to mask taste
