Soft tissue tumours

Question 1

Lipoma is _________ (benign/malignant) tumor which is most common soft tissue tumor of adulthood.

Answer 1

benign

Question 2

What are the common locations where lipoma occurs?

Answer 2

superficial extremities and trunk

Question 3

What are the morphological features of a lipoma?

Answer 3

Mature adipocytes are found

Question 4

What is the Tx of lipoma?

Answer 4

simple excision

Question 5

Liposarcoma is a malignant tumor and it has three morphological types. Name them.

Answer 5

Well-differentiated liposarcoma
Myxoid liposarcoma
Pleomorphic liposarcoma

Question 6

What are the common locations where well-differentiated liposarcoma occurs?

Answer 6

Deep extremities and retroperitoneum

Question 7

What are the common locations where myxoid liposarcoma occurs?

Answer 7

Thigh and leg

Question 8

What are the morphological features of a well-differentiated liposarcoma

Answer 8

Adipocytes with scattered atypical spindle cells

Question 9

What are the morphological features of a myxoid liposarcoma?

Answer 9

Myxoid (basophilic) matrix
Chicken wire vessels
round cells
lipoblasts

Question 10

What are the morphological features of a pleomorphic liposarcoma?

Answer 10

Sheets of anaplastic cells
Bizarre nuclei
Lipoblasts

Question 11

Amplification of _________ is characteristic of well differentiated liposarcoma

Answer 11

12q13-q15

Question 12

________ translocation is characteristic of myxoid liposarcoma

Answer 12

t(12;16)

Question 13

The amplified region of chromosome 12q is ______ which is a potent inhibitor of p53.

Answer 13

MDM2

Question 14

The _____________ liposarcoma is indolent

Answer 14

well-differentiated

Question 15

The pleomorphic liposarcoma is __________ (indolent/aggressive)

Answer 15

aggressive

Question 16

The myxoid liposarcoma is __________ (severe/intermediate/mild) in its malignant behavior

Answer 16

intermediate

Question 17

Myxoid liposarcoma is also called _________ liposarcoma

Answer 17

round cell liposarcoma

Question 18

Nodular fascilitis is a _________ (benign/malignant) fibrous tumor.

Answer 18

benign

Question 19

What are the common locations of nodular fascilitis?

Answer 19

Arm and forearm

Question 20

What are the morphological features of nodular fascilitis?

Answer 20

Tissue culture like fibroblast growth
Extravasated erythrocytes
Lymphocytes
No neutrophils
Stellate to spindle cells with mitotic activity

Question 21

A history of _______ (trauma/smoking) is present in 25% cases of nodular fascilitis

Answer 21

trauma

Question 22

Nodular fascilitis is not larger than ___ cm and grows rapidly in several weeks or months

Answer 22

5 cm

Question 23

What is the genetic abberation in nodular fascilitis?

Answer 23

t(17;22) that produces MYH9-USP6 fusion gene

Question 24

Fibromatoses are of two types
Superficial
Deep
Where do these occur?

Answer 24

Superficial fibromatosis in palms, plantar fascia and penis

Deep fibromatosis in abdominal wall