Seronegative Spondyloarthropathies Flashcards
What are the features of Seronegative Spondyloarthropathies?
Absence of Rheumatoid factor
Association with HLA-B27
Sacroiliac joints involved, w/ or w/o other joints
Pathologic changes in the ligamentous attachments rather than synovium
The manifestations of SSA are immune-mediated and are triggered by ______ response
T cell
What joints are most commonly involved in ankylosing spondylitis?
sacroiliac joints
apophyseal joints
What happens in ankylosing spondylitis?
destruction of articular cartilage and bony ankylosis
What age group is most commonly affected in ankylosing spondylitis?
The 20s and 30s
What are the symptoms of ankylosing spondylitis?
lower back pain and spinal immobility
Ankylosing spondylitis has an association with ______ receptor gene
IL-23
Involvement of peripheral joints in at least ________ of affected individuals in ankylosing spondylitis.
1/3
An anti _______ antibody has shown some efficacy in ankylosing spondylitis
IL-17
Why is there kyphosis (stooped posture) in ankylosing spondylitis?
Fusion of the vertebral column occurs, also known as the bamboo spine.
What does kyphosis lead to in ankylosing spondylitis?
kyphosis interferes with chest wall movement leading to non-pulmonary restrictive lung disease.
It also causes compensatory hyperextension of neck
Loss of lumbar lordosis
What is Schober’s test?
Schober’s test assesses the amount of lumbar flexion
What are the extra-articular findings in ankylosing spondylitis?
(A5B)
Anterior uveitis Achilles tendonitis Aortitis with aortic regurgitation Asymptomatic inflammation of the proximal colon and terminal ileum Amyloidosis Bilateral apical pulmonary fibrosis
What peripheral joints are commonly involved in ankylosing spondylitis?
hips
knees
shoulders
What are the lab findings?
specifically about ESR, CRP, serum IgA, CBC, and ALP
High ESR High CRP High serum IgA Mild anemia High ALP
