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Antiepileptics > Sodium Valproate > Flashcards

Sodium Valproate Flashcards

1
Q

MoA

A

Voltage-gated Na+ channels
Inhibitor
Inhibit inactivation of inhibitory NT GABA and block its reuptake into neurones
Inhibition of AP transmission both pre- + post-synaptically
Increased levels of GABA in brain and interruption of seizure activity

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2
Q

Indications

A

Epilepsy
Acute Mania
Maintenance treatment for Bipolar Disorder

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3
Q

ADR

A 
Valproate SEs
Appetite increase and weight gain
Liver failure
Pancreatitis
Reversible hair loss
Oedema
Ataxia
Tertaogenicity, Tremor, Thrombocytopenia
Encephalopathy ( confusion as elevated ammonia )
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4
Q

Prescribing Advice

A

Avoid in Obesity + Pregnancy
Check FBC at baseline
X Hepatic disease

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Antiepileptics (6 decks)

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