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Antiepileptics > Carbamazepine > Flashcards

Carbamazepine Flashcards

1
Q

MoA

A

Voltage-gated Na+ channels
Use-dependent blockade
Slows recovery of voltage-gated Na+ channels
Opens K+ channels
Promotes GABA release
Reduces excitability/blocks excitation of neurones that are firing repeatedly

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2
Q

Indications

A

Epilepsy
Trigeminal neuralgia
Prophylaxis of Bipolar Disorder

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3
Q

ADR

A 
Diplopia
Ataxia
Sedation
Fatigue
Hyponatraemia -SIADH:
Increase ADH
Rash
Stevens-Johnson's
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4
Q

Prescribing Advice

A

Higher dose of oral contraceptives
Avoid in obesity
Monitor plasma conc, FBC

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Antiepileptics (6 decks)

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