Lamotrigine Flashcards
1
Q
MoA
A
Voltage-gated Na+ channels –> selectively binds to inactivated state of channel
Inhibitor
Blocks repetitive firing of neurones by delaying membrane recovery
Stabilises presynaptic neuronal membrane
Suppresses release of excitatory AA glutamate –> key role in generation of seizures
2
Q
Indications
A
Epilepsy
Bipolar
SAFE IN PREGNANCY
3
Q
ADR
A
Rash - Stevens-Johnson’s Syndrome
Minimised by slow titration
Insomnia
Less cognitive effects
4
Q
Prescribing Advice
A
Interactions: OCP, other AEDs
Rash more likely in children