Sodium Salicylate Tablets USP

Question 1

Place not less than ______ in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 1

20 tablets

Question 2

Place not less than 20 tablets in a 200 mL volumetric flask, add ______of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 2

100 mL

Question 3

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about _____ of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 3

500 mg

Question 4

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add ______ and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 4

75 mL of ether

Question 5

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and _______, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 5

10 drops of bromophenol blue TS

Question 6

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with ________, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 6

0.1 N hydrochloric acid VS

Question 7

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, _______ is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to 16.01 mg of C7H5NaO3

Answer 7

pale green color

Question 8

Place not less than 20 tablets in a 200 mL volumetric flask, add 100 mL of water and allow to stand, with frequent agitation, until the tablets disintegrate completely. Dilute with water to volume, a mix. Filter through a dry filter into a dry flask, discarding the first 10 mL of the filtrate. Transfer an accurately measured volume of the subsequent filtrate, equivalent to about 500 mg of sodium salicylate, to a separator, and dilute with water, if necessary, to make about 25 mL. Add 75 mL of ether and 10 drops of bromophenol blue TS, and titrate with 0.1 N hydrochloric acid VS, Mixing the water and ether layers by vigorous shaking until a permanent, pale green color is produced in the water layer. Draw off the water layer into a small flask, wash the ether layer once with 5 mL of water, and add this to the water layer. Continue the titration with vigorous shaking until a permanent, green color is produced in the water layer. Each mL of 0.1 N hydrochloric acid in equivalent to _____ of C7H5NaO3

Answer 8

16.01 mg

Question 9

Sodium Salicylate: Type of chemical reaction

Answer 9

Neutralization: acidemetric

Question 10

Sodium Salicylate: type of titration

Answer 10

Direct titration

Question 11

Sodium Salicylate: Indicator

Answer 11

Bromophenol blue TS

Question 12

Sodium Salicylate: Endpoint

Answer 12

pale green

Question 13

Sodium Salicylate tablets official requirement

Answer 13

Sodium Salicylate Tablets contain not less than 95.0 percent and not more than 105.0 percent of labeled amount of C7H5NaO3

Question 14

MW of Sodium Salicylate

Answer 14

160.11