Sodium Balance Flashcards
Hyponatremia - Value?
135
Hyponatremia - Types (2)
- Pseudo - Does not cause HypoOsmollalilty (Asymptomatic)
2. True - Cause HypoOsmollality (Symtpomatic or Asymptomatic)
Water in Body?
TBW - 60% of BW
- ICF - Intra Cellular Fluid 60%
- ECF - Extra Cellular Fluid 40%:
- Interstititum - 80% of ECF
- Plasma - 20% ECF
Plasma Osmollality Calculation
POsm = 2 x P[Na+] + [Glu]/18 + BUN/2.8
Normal - 275-290
Plasma Tonicity Calculation
PTonicity = Effective Posm = 2 x P [Na+] + [Glu]/18
Hyponatremia clinical signs
Asymptomatic Symptomatic - Mostly Neurological: 1. nausea, malaise 2. headache 3. lethargy 4. irratability 5. supor 6. comma
Pseudohyponatremia - Ethologies (3)
- Hyperglicemia (HyperTonic)
- Hyperlipidemia (IsoTonic)
- HyperProteinemia (IsoTonic)
Sodium correction for HyperGlycemia?
1.4 for every 100 above 100mg/dl glucose
Pseudohyponatremia - Types (2)
- Isotonic - Hyperlipidemia + Hyperproteinemia
2. Hypertonic - Hyperglycemia / IV Manitol
True-Hyponatremia - Types (3):
- Hypovolemia - Decreased TBNa
- Hypervolemia - Increased TBNa
- Normovolemia - Normal TBNa
Hypovolemia - Decreased TBN - Casuses(2)?
Tachycardia, Hypotension
- Renal / Diuretics - Una>20meq/L (Disothiazide > Fusid )
- Extra renal - Skin / GIT - UNa<20meq/L
Hypovolemia - Decreased TBN - Clinics
- Hypotension
- Tachycardia
- Dry mucos
Hypovolemia - Decreased TBN - TX?
- Cause
2. Normal Saline - isotonic - 0.9%
Hypervolemia - Increased TBNa - Casuses (4)?
Clinics: Edema, Ascitis 1. CHF 2. Cirrhosis 3. Nephrotic synd UNa < 20meq/
True-Hyponatremia - Hypervolemia - Urinary Sodium level?
א”ס לב, צרוזיס : מתחת 20meq/L
תסמונת נפרוטית: מתחת 20meq/L
באיבוד בכליות: מעל 20meq/L