social sector services- health, education and HR; poverty and hunger Flashcards
Atal Community Innovation Centre
- by AIM
- aims at spurring community Innovation in underserved and unserved areas of the country through solution driven design thinking to serve the society
- ACIC will be established either in PPP mode or with support of PSUs and other agencies.
- maximum grant-in-aid support frm AIM will be up to 2.5 crores subject to following compliance to ACIC guidelines and contributing matching frm the host institutions and their funding partner(s)
- serve as the bridge between the knowledge base existing in communities and the advanced technical ecosystem prevalent in the market base and the needs of society
National Digital Health Blueprint?
- lays out the ‘building blocks’ for the implementation of the National Health Stack (NHS), which aims to deploy AI in leveraging health records. In doing so, it lays down the following objectives:
- To establish national and regional registries to create single source of truth in respect of Clinical Establishments, Healthcare Professionals, Health Workers and Pharmacies.
- Creating a system of Personal Health Records accessible to the citizens and to the service providers based on citizen-consent.
- Promoting the adoption of open standards by all the actors in the National Digital Health Ecosystem.
- Promoting Health Data Analytics and Medical Research.
- In line with ‘data as a public good’, the blueprint proposes the linking of multiple databases to generate greater and granular data that can be leveraged by the public as well as private sector – including insurance companies, hospitals, apps and researchers.
- blueprint proposes a National Digital Health Mission “as a purely government organisation with complete functional autonomy on the lines of existing National Information Utilities like UIDAI and GSTN
Availability of Doctors in INdia?
- India has a doctor-population ratio of 1:1456 as compared with the WHO standards of 1:1000
- India has a doctor-population ratio of 1:1456 as compared with the WHO standards of 1:1000
- India has a doctor-population ratio of 1:1456 as compared with the WHO standards of 1:1000
Rotavirus?
- Rotavirus is a leading cause of severe diarrhoea and death among children less than five years of age.
- It is responsible for around 10% of total child mortality every year.
- some rotavirus infections cause few or no symptoms, especially in adults.
- Rotavirus is transmitted by the faecal-oral route, via contact with contaminated hands, surfaces and objects, and possibly by the respiratory route. Viral diarrhea is highly contagious.
- Rotavirus diarrhoea presents in similar manner like any other diarrhoea but can mainly be prevented through rotavirus vaccination. Other diarrhoea can be prevented through general measures like good hygiene, frequent hand washing, safe water and safe food consumption, exclusive breastfeeding and vitamin A supplementation.
National Youth Awards?
- for excellent work and contribution in different fields of development and social service such as health, promotion of human rights, active citizenship, community service etc.
- conferred on individuals (aged between 15-29 years) and organizations
- given by the Ministry of Youth Affairs and Sports, Department of Youth Affairs.
TEQIP?
- Technical Education Quality Improvement Programme launched in 2002 by MHRD with assistance of WB
- programme aimed to overhaul the quality of technical education in the Low Income States and Special Category States (SCS) in India
- ended in March 2021, leaving more than 1,200 assistant professors out of a job and some rural colleges bereft of half their faculty.
- GoI is planning to replace TEQIP with a similar project called MERITE
Measures included:
- Institution based: accreditation of the courses through NBA, governance reforms, improving the processes, digital initiatives, securing autonomy for the colleges.
- Student based: improving the quality of teaching, teacher training, equipping the class rooms, industry interaction, compulsory internships for students, training the students in industry-relevant skills, preparing them for the GATE exam
National Essential Diagnostics List (NEDL)?
- India’s First NEDL compiled by ICMR
- With this, India has become the first country to compile such a list that would provide guidance to the government for deciding the kind of diagnostic tests that different healthcare facilities in villages and remote areas require.
- The list is meant for facilities from village till the district level. NEDL builds upon the Free Diagnostics Service Initiative and other diagnostics initiatives of the Health Ministry to provide an expanded basket of tests at different levels of the public health system.
- implementation of NEDL would enable improved health care services delivery through evidence-based care, improved patient outcomes and reduction in out-of-pocket expenditure; effective utilisation of public health facilities. It would help in effective assessment of disease burden, disease trends, surveillance, and outbreak identification; and address antimicrobial resistance crisis too.
- In India, diagnostics (medical devices and in vitro diagnostics) follow a regulatory framework based on the drug regulations under the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules 1945.
notifiable disease?
- A notifiable disease is any disease that is required by law to be reported to government authorities.
- WHO’s International Health Regulations, 1969 require disease reporting to the WHO in order to help with its global surveillance and advisory role.
- The onus of notifying any disease and the implementation lies with the state government.
- Any failure to report a notifiable disease is a criminal offence and the state government can take necessary actions against defaulters.
- The Centre has notified several diseases such as cholera, diphtheria, encephalitis, leprosy, meningitis, pertussis (whooping cough), plague, tuberculosis, AIDS, hepatitis, measles, yellow fever, malaria dengue, etc.
MDR-TB?
- People with TB who do not respond to at least isoniazid and rifampicin, which are first-line TB drugs are said to have MDR-TB.
- As per WHO’s Global Tuberculosis Report 2018, an estimated 4.5 lakh people across the world have MDR-TB
- India has 24% of MDR-TB cases in the world
XDR-TB?
- People who are resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (amikacin, kanamycin, or capreomycin) are said to have XDR-TB.
- As per WHO’s Global Tuberculosis Report 2018, nearly 37,500 people have XDR-TB.
- By the end of 2017, XDR-TB had been reported from 127 countries, including India.
National Sports Awards?
- Rajiv Gandhi Khel Ratna Award is given for the spectacular and most outstanding performance in the field of sports by a sportsperson over a period of four year.
- Arjuna Award is given for consistency outstanding performance for four years.
- Dronacharya Award for coaches for producing medal winners at prestigious International sports events.
- Dhyan Chand Award for life time contribution to sports development.
- Rashtriya Khel Protsahan Puruskaris given to the corporate entities (both in private and public sector) and individuals who have played a visible role in the area of sports promotion and development.
- MAKA Trophy:Overall top performing university in inter-university tournaments is given Maulana Abul Kalam Azad (MAKA) Trophy.
Pretomanid?
- USFDA has approved a new drug Pretomanid for treating drug-resistant tuberculosis- MDR-TB and XDR-TB
- Pretomanid is only the third new anti-TB drug approved for use by FDA in more than 40 years.
- duration of treatment for drug-resistant TB can be drastically cut from 18-24 months to just six-nine months when pretomanid drug is used along with two already approved drugs — bedaquiline and linezolid.
- The all-oral, three-drug regimen can also vastly improve the treatment success rate
What does the ‘efficacy’ of a vaccine mean?
Efficacy looks at the ability of the vaccine to protect the inoculated population using various parameters — ranging from the ability of the shot to prevent mild to severe symptoms from showing even if you have been infected, to preventing you from getting infected with the disease altogether.
In the case of Covid-19 vaccines, pharma companies have primarily focussed on bringing down the number of symptomatic cases — even if you’re infected with SARS-CoV-2, you may not present with the symptoms and fall as sick as you would have without the vaccine.
What is Malana Cream??
- It is the charas or hash or hashish which comes from the Malana Valley in Kullu district of Himachal Pradesh.
- Charas, called bhang in Himachal, is the resin obtained from a species or strain of the cannabis plant, which grows naturally in the valley and is also cultivated illegally.
- A high proportion of THC (tetrahydrocannabinol, the primary psychoactive constituent) in the plant extract is required for recreational drug use and Malana Cream is believed to be particularly rich in THC, making it more potent. Resin extracted from the plant, generally by rubbing using hands, is also concentrated further to obtain the more potent hash oil.
- With greater road connectivity, Malana and its neighbouring Parvati Valley became notorious for ‘drug tourism’
- the plant grows naturally in the area, so it cannot be eliminated altogether.
legality of cannabis cultivation is INdia?
- In 1985, India banned the cultivation of cannabis plant under the Narcotic Drugs and Psychotropic Substances (NDPS) Act.
- But this Act allows state governments to allow controlled and regulated cultivation of hemp for obtaining its fibre and seed for industrial or horticultural purposes. In 2018, Uttarakhand became the first state in the country to do so, allowing the cultivation of only those strains of cannabis plant which have a low concentration of THC. similar policy in UP, MP, Manipur and most recently in HP
- Currently, charas, ganja, or any mixture or drink prepared from the two products are banned in India under the NDPS Act, regardless of hemp cultivation.
- illegality of cannabis has made it a contentious issue in Himachal, since it has a certain cultural acceptance in the state.
vaccine wastage?
- Different stages where wastage occurs:
- Cold chain points.
- District vaccine stores.
- Vaccination session site
- how wastage happes:
- in unopened vials
- expired
- exposed to heat
- frozen
- breakage
- theft
- in opened vials
- discarding leftover doses
- vials submerged in water
- contamination
- poor vaccine administration
- in unopened vials
- At the end of March 2021, vaccine wastage % was 6%, against centre’s guidelines of limiting it to 1%. some states lke Telangana had vaccine waste at 17.6%
NISHTHA?
National Initiative for School Heads and Teachers Holistic Advancement
- by MHRD
- world’s largest teachers’ training programme of its kind in the world. Aims to build capacities of around 42 L participants covering all teachers and Heads of Schools at the elementary level in all Government schools etc.
- launched to improve Learning Outcomes at the Elementary level.
- basic objective of this massive training programme is to motivate and equip teachers to encourage and foster critical thinking in students.
- nitiative is first of its kind wherein standardized training modules are developed at national level for all States and UTs. However, States and UTs can contextualize the training modules and use their own material and resource persons also
Janaushadhi Sugam?
- A mobile app launched by Min of Chemicals and Fertilisers
- aims to enable people to search Janaushadhi generic medicines and the stores at the tip of their fingers.
- It will also help analyse product comparison of Generic vs Branded medicine in form of MRP & overall Savings.
implementing agency of Pradhan Mantri Bhartiya Janaushadhi Pariyojana?
Pharmaceuticals & Medical Devices Bureau of India (PMBI) formely known as Bureau of Pharma PSUs of India (BPPI)
National Digital Library of India?
- by MHRD
- project under the aegis of National Mission on Education through Information and Communication Technology (NMEICT).
- under the aegis of National Mission on Education through Information and Communication Technology (NMEICT).
- objective of NDL is to make digital educational resources available to all citizens of the country to empower, inspire and encourage learning.
- NDL is the Single Window Platform that collects and collates metadata from premier learning institutions in India and abroad, as well as other relevant sources.
NMEICT?
- National Mission on Education through Information and Communication Technology (ICT) has been envisaged as a Centrally Sponsored Scheme to leverage the potential of ICT, in teaching and learning process for the benefit of all the learners in Higher Education Institutions in any time anywhere mode.
- Mission has two major components – providing connectivity, along with provision for access devices, to institutions and learners; and content generation.
- Mission aims to extend computer infrastructure and connectivity to over 25000 colleges and 2000 polytechnics in the country including each of the departments of 419 universities/deemed universities and institutions of national importance as a part of its motto to provide connectivity up to last mile.
Fit India Movement ?
Prime Minister launches nation-wide Fit India Movement on the occasion of National Sports Day (29th Aug)
On this Day, President confers the National Sports Awards, National Adventure Awards, Arjuna Award, Khel Ratna, Dronacharya Award and Dhyanchand Award to recognise the exceptional achievements of Indian sportspersons.
T/F: ICMR has recommended ‘complete’ ban on Electronic Nicotine Delivery Systems (ENDS), including e-cigarettes.
T
Shagun?
- one of world’s largest Integrated Online Junction for – School Education
- by MHRD
- It is an over-arching initiative to improve school education system by creating a junction for all online portals and websites relating to various activities of the Department of School Education and Literacy.
- The word Shagun is coined from two different words- ‘Shala’ meaning Schools and ‘Gunvatta’ meaning Quality.
food wastage in India: stats?
supply chain loss
- As per FAO, Nearly 40 per cent of the food produced in India is wasted every year due to fragmented food systems and inefficient supply chains.
- while the annual cost of food security is ~1.5Lcr, >90000cr worth of farm produce is waste annually
- About 21 million tons of wheat is wasted in India
- India ranks 94th among 107 countries in GHI 2020
- 25% of fresh water used to produce food is ultimately wasted
HH loss
- food waste generated in our homes is 50kgper person per yr acc to Food waste index report 2021
- This excess food waste usually ends up in landfills, creating potent greenhouse gases which have dire environmental implications.
- 300 million barrels of oil are used to produce food that is ultimately wasted.
Household food wastage in India: suggestions?
- organisations such as Coimbatore-based No Food Waste which aim to redistribute excess food to feed the needy and hungry. Adrish, India’s first chain of zero-waste concept stores, which is focused on getting people to shift from harmful, artificial consumption to an eco-friendly, zero-waste lifestyle.
- We must attempt to change our “food abundance” mindset to a “food scarcity” one
- Regional Indian recipes like surnoli, a Mangalorean dosa made with watermelon rind, or gobhi danthal sabzi made with cauliflower stalks and leaves in Punjab, are born out of the ideas of frugality and respect for our food. Bengalis adopt a root-to-shoot philosophy throughout their cuisine — thor ghonto is a curry comprising tender banana stems, while ucche pata bora are fritters made with bitter gourd leaves.
National Mental Health Programme (NMHP): need?
Lancet Report- India
- 197.3 million people were reported to have mental disorders in 2017.
- 45.7 million people suffered depression in 2017.
- 44.9 million people suffered with anxiety in 2017.
- The contribution of mental disorders to the total Disability-Adjusted Life-Years (DALYs) in India increased from 2·5 percent in 1990 to 4·7 percent in 2017.
Acc to NCRB data
- India reported an average 381 deaths by suicide daily in 2019
National Mental Health Programme (NMHP): about?
- launched by GoI in 1982
- 3 components
- treatment of mentally ill
- rehabilitation
- prevention and promotion of positive mental health
- obj:
- ensure availability and accessibility of minimum mental health care for all, esp most vulnerable
- encourage application of mental health knowledge in general health care and in social development.
- promote community participation in the mental health services development
- aims to integrate mental health with primary health care through the NMHP, providing treatment for mental disorders at tertiary care institutions and eradicating stigmatization
- proposed allocation for NHMP in FY 21 — Rs 40 crore — is too small an amount to handle mental health impact and fallouts of the COVID-19 pandemic.
legal obligations imposed on govt to ensure public and individual health, even at the cost of individual liberty in case of public health emergencies?
- Art 21 interpreted under RC Cooper v UoI and Maneka Gandhi case
- DPSP: Art 39(f) read along with Art 47
- India is a prty to International Covenant on Economic, Social and Cultural Rights (ICESCR), Art 12 of which postulates that states are required to take all possible measures to progressively realise the enjoyment of “highest attainable standards of physical and mental health” of its citizens.
- Art 253enables Parliament to implement and discharge its onerous international obligations created by various treaties, which have been duly ratified.
- landmark judgment of Vishaka v. State Of Rajasthan (1997), where it was remarked that the state should adhere to the ratified international agreements and enforce them by enacting necessary legislations.
- Delhi HC judgement that declared private vehicle as public space with regards to mask wearing mandate in Delhi in wake of Corona, for the larger cause of public health.
- Preamble: preservation of “public health”, ensures the “fraternity assuring the dignity of an individual”, leading subsequently to the achievement of “unity and integrity of a nation”
Anti-microbial resistance and environmental pollution/degradation?
Acc to WHO, AMR is one of the top ten threats to global health. number of deaths linked to AMR will increase to 10 million per year by 2050.
focus on environmental contamination by antibiotics has been limited.
- main cause of antibiotics in the environment is the effluent discharge of APIs frm mfg units, tat contains high concentrations of antibiotic residues that can lead to hotspots of resistant bacteria further contributing to AMR
- study conducted by IIT Madras in and around Chennai indicated a high concentration of antimicrobial agents in the rivers and lakes in the vicinity of pharmaceutical plants and outlets of wastewater treatment plants.
- Currently, there are no global standards for antibiotic discharge limits in the environment from pharmaceutical industries. India is the only country to have issued the Draft Environment Protection Amendment Rules in January 2020 to limit the amount of antibiotic residue permitted in wastewater released by drug factories. If notified, it will shift the paradigm from a focus on the quality of medicine to the impact, manufacturing has on workers and the environment.
- none of the world’s 17 biggest antibiotic producers publishes particulars of the levels of antibiotic residue discharged in wastewater, as per the 2020 AMR Benchmark report by the Access to Medicines Foundation
Drug resistant typhoid strain?
- significance
- 11 mn infections
- more than 100000 deaths per yr
- South Asia accounts for > 70% of global disease burden
- since 2000, MDR S Typhi has declined steadily in BN and INdia and remained low i Nepal and increased slightly in Pakistan
- however, these MDR are now being replaced by strains resistant to other antibiotics as well
- MoHFW is considering introducing new typhoid conjugate vaccines into national immunisation programme
Malnutrition in INdia: stats?
- NFHS-4
- >1/3rd under 5 Children suffer from stunting and wasting
- 14% of India’s pop doesn’t get enough calories
- 35% children stunted, 17.3% are wasted
- 40% of children betn 1 and 4 yrs are anemic
- >50% oregnant and non-pregant women were anemic
- under-5 Mortality rate is 3.7%
- 21 per cent of children under-5 suffered from Moderate Acute Malnourishment (MAM) and 7.5 per cent suffered from Severe AM
- Acc to Global Nutrition Report 2020, India will miss targets, for all the four nutritional indicators for which there is data available, i.e. stunting, anaemia, childhood overweight and exclusive breastfeeding.
- rural vs urban: stunting prevalence being 10.1% higher in rural vs urban areas
- INdian slipped from 94th to 102nd rank in GHI 2021, lower thna neighbours like PK and BN
- Malnutrition affects cognitive ability, workforce days and health, impacting as much as 16% of GDP (World Food Programme and World Bank
- According to a study by Lancet, 68 per cent of the under-5 deaths in India can be attributed to malnutrition.
- India is home to nearly half of the world’s “wasted or acute malnourished” children of the world
- Despite various targeted outreach and service delivery programmes, 16 out of the 22 states and UTs have still shown an increase in SAM, as per NFHS-5 conducted in 2019-20.
- According to a study published in journal Global Health Science 2020, the challenges induced by COVID-19 are expected to push another four million children into acute malnutrition.
Role of community in battling malnutrition?
- Acute malnutrition is a complex socio-cultural problem that lies at the interplay of inequitable access to nutritious foods and health services, sub-optimal infant, and young child-feeding practices incl breastfeeding, low maternal education, poor sanitation and hygiene.
- 70-80% of malnutritioned children face no medical complications or hospitalizations and thus Community Management of Acute Malnutrition (CMAM) can be feasible in these cases
- CMAM is recommended by both WHO and UNICEF and has shown positive results across many countries and some of the states and district in India
- case study: in 2007, the MH govt went on to implement CMAM at four different levels in the Nandurbar district.
- first step involved community level screening, identification, and active case finding of SAM children by Anganwadi/ASHA workers.
- second step initiated treatment of SAM children without any complications at community level through Village Child Development Centre (VCDC) by using different centrally and locally produced therapeutic food. These are energy dense formulations fortified with critical macro and micro nutrients
- third step included treatment of children with complications at the NRCs (Nutrition Rehabilitation Centres).
- fourth step involved following-up of children discharged from the CMAM programme to avoid a relapse, along with promotion of good IYCF practices, child stimulation for development, hygiene
- As a result, the district witnessed a decline in SAM children — from 15.1 per cent in 2015-16 (NFHS-4) to 13.5 per cent in 2019-20 (NFHS-5).
idea of ‘exchange entitlement decline’ for explanation of starvation?
- proposed by Amartya Sen
- idea of ‘exchange entitlement decline’ is characterised by an adverse shift in the exchange value of endowments for food. It essentially means the occupation a section of people are engaged in is not remunerative enough to buy adequate food.
- Though Sen postulated this theory to describe reasons for famines, we may look at it to understand the hunger situation in our country.
- Sen talked about four categories of entitlement: ‘Production-based entitlement’ (growing food); ‘trade-based entitlement’ (buying food); ‘own-labour entitlement’ (working for food); and ‘inheritance and transfer entitlement’ (being given food by others).
- He postulated that individuals face starvation if their full entitlement set does not provide them with adequate food for subsistence. The idea that starvation is a result of decline in entitlements, is contrary to the Malthusian idea that identifies ‘more people less food’ as the reason for starvation.
Applying this idea to India’s hunger and malnutrition problem, one can figure out four-pronged reasons
- Though we have surplus food, most small and marginal farming households do not produce enough food grains for their year-round consumption.
- Second, relative income of one section of people has been on the decline.
- Third, the kind of work a section of people have been doing are less remunerative or there is less opportunity to get remunerative works.
- Fourth, the PDS of the state is not functioning well or is not accessible to everyone.
“A single price for OVID vaccine will be most advisable to ensure efficient vaccination”: arguments?
In actuality, the latest govt policy requires vaccine manufacturers to supply 50% of their prodn to the Centre at controlled prices, while allowing them to sell the remaining half in the open market (incl SGs) at pre-announced “self-set” prices.
- this policy susceptible to market failure. vaccines have a significant positive externality as well. It not only protects the vaccinated but also other people. Since every individual ignores the full set of benefits/costs from consuming goods with +ive/-ive externalities, the market isn’t always the most efficient mechanism for allocation of such goods. It leads to “under-provision” or “over provision”. That is a key reason why governments treat goods having large positive externalities as “public goods” and provide these while factoring in the full costs and benefits to society.
- no limit per se on retail prices
- can lead to diversion of supplies from controlled low price govt centres to open mkt
- This could lead to a whole range of prices and vaccine inequality
- Vaccine inequality: we may well have scarcity in the “mass” segment co-existing with a glut in the “elite” segment.
- Apart from the ethical aspects, it is also inefficient. The ones who are most prone to suffering from and spreading COVID will be the ones who will be facing vaccine shortage the most i.e. small traders, vendors etc. And the people who will get the earliest ones will be the one who can afford working from home.
A better alternative can be a single price throughout the country and govt paying for the poor sections as in case of fertiliser subsidy
Neglected tropical diseases?
- They are infections that are most common among marginalised communities in the developing regions of Africa, Asia and the Americas.
- Caused by a variety of pathogens such as viruses, bacteria, protozoa and parasitic worms.
- They generally receive less funding for research and treatment than malaises like tuberculosis, HIV-AIDS and malaria.
- Some examples include snakebite envenomation, scabies, yaws, trachoma, Leishmaniasis and Chagas disease.
NTDs affect more than a billion people globally. They are preventable and treatable. However, these diseases — and their intricate interrelationships with poverty and ecological systems — continue to cause devastating health, social and economic consequences.
Policies on neglected diseases research in India:
The National Health Policy (2017) sets an ambition to stimulate innovation to meet health needs and ensure that new drugs are affordable for those who need them most, but it does not specifically tackle neglected diseases.
The National Policy on Treatment of Rare Diseases (2018) includes infectious tropical diseases and identifies a need to support research on treatments for rare diseases. It has not yet prioritised diseases and areas for research funding or how innovation would be supported.
major neglected tropical diseases?
- Dengue
- Rabies
- Trachoma
- Yaws
- Leprosy
- Chagas disease
- sleeping sickness
- Leischmaniases
- guinea worm disease
- schistosomiasis
H10N3?
- It is a type of bird flu, common in wild aquatic birds and can infect domestic poultry and other bird and animal species
- China has reported the world’s first human infection of the H10N3 bird flu strain.
- Infected birds shed avian flu in their saliva, mucus, and poop, and humans can get infected when enough of the virus gets in the eyes, nose, or mouth, or is inhaled from infected droplets or dust.
- H10N3 is a low pathogenic or relatively less severe strain of the virus in poultry and the risk of it spreading on a large scale is very low.
influenza virus classification?
Influenza viruses can also be classified into 4 subtypes
- influenza A: can be found in many species, including humans, birds, and pigs. Due to the breadth of potential hosts and its ability to genetically change over a short amount of time, influenza A viruses are very diverse.
- further classified into subtypes based on two surface proteins, Hemagglutinin (HA) and Neuraminidase (NA). For example, a virus that has an HA 7 protein and NA 9 protein is designated as subtype H7N9.
- Influenza B is typically only found in humans.
- Influenza C mainly occurs in humans, but has been known to also occur in dogs and pigs.
- Influenza D is found mainly in cattle. According to the CDC, it’s not known to infect or cause illness in humans.
emergence of China as ground zero for new and mysterious diseases?
SARS outbreak in 2003 was linked to the animal market in China and the H7N9, which spread in China in 2013, was linked to a market of live birds.
last human epidemic of bird flu in China occurred in late 2016 to 2017, with the H7N9 virus.
factors responsible
- China sees a lot of unsafe animal-human interaction, which is behind the spread of most of these zoonotic viruses, which transmit from animals to humans.
- unlike India, the animal markets (wet markets) have live animals, which are kept in closed space and culled for fresh meat.
- These places are frequented by a lot of people and are a hotbed of infections; so if one human gets infected, it will only spread
- High population density and developed transport links aid rapid spread of viruses.
Bird flu in humans?
- can be transmitted directly to humans
- first known cases in humans were reported in 1997, when an outbreak of avian influenza A virus subtype H5N1 in poultry in Hong Kong.
- Small outbreaks of bird flu caused by other subtypes of the virus have also occurred. eg. H7N7 in Netherlands in 2003
- subtypes of bird flu viruses:
- mild
- highly virulent and contagious: called ‘fowl plague’
- With few exceptions (e.g., H5N1, H7N9), most H5, H7, and H9 subtypes are low pathogenecity
- Although isolated instances of person-to-person transmission appear to have occurred since 1997, sustained transmission has not been observed. However, through a rapid evolutionary process called antigenic shift, two viral subtypes—e.g., one a bird flu virus such as H5N1 and the other a human influenza virus—can combine parts of their genetic makeup to produce a previously unknown viral subtype.
T/F:
- India was declared free from H5N1 avian influenza.
- WHO is the agency responsible for declaring countries free from avian influenza
- status will only last until the next outbreak occurs
- Spanish flu of 1918 was caused by H1N2 subtype of influenza A virus
- T; multiple times eg. in 2017, 2019
- F; OIE-World Organisation for Animal Health
- T
- F; H1N1
T/F: not all subtypes of influenza A viruses can infect birds.
T
all except H17N10 and H18N11 which have only been found in bats
Plasmodium Vivax is related to?
Malraria
T/F: India has highest incidence of Plasmodium Vivax malaria
T (47%)
Malaria drop in India in last one yr?
2.6 mn fewer cases in 2018, sharpest absolute decline in world
Malaria cases have declined in all other major regions except?
Westen pacific
Seven states accounting for 90% of malaria cases in india?
UP, JH, CHH, WB, GJ, Odisha and MP
price cap on non-scheduled drugs: present system?
-> Currently, NPPA fixes prices of scheduled drugs (medicines under price control) -> The prices of non-scheduled drugs can be raised by up to 10% a year. -> For nonscheduled drugs, the industry norm has been to give 10% margin to stockists and 20% to retailers. -> However, there have been allegations that actual margins are far higher.
Government’s proposal wrt price cap on non-scheduled drugs? Benefits?
cap trade margins for all medicines outside price control at 30% (10%+ 20%) 1) Although some say that there is already this cap, By making trade margins explicit, there will be less scope for exploitation by large institutions 2) expected to reduce the prices of nearly 80% of formulations. Non-scheduled drugs, or formulations outside price control, account for Rs 10,000 crore of sales in the Rs 1-lakh-crore Indian drug market. There are currently 10600 non scheduled drugs
trade margin of pharma drugs: what is it?
difference between the price at which manufacturers/importers sell to stockists and the price charged to consumers.
T/F: Drugs priced less than Rs 5 per unit are exempted from trade margin caps.
F
% of India’s total healthcare spending goes towards medicines?
70%
Causes of antibiotic resistance?
- over-prescribing
- Patients not finishing their treatment course
- over-use of antibiotics in livestock and fish farming
- poor infection control in hospitals and clinics
- lack of hygiene and poor sanitation
- lack of new antibiotics being develped.
Over-Prescription in India: stats?
Public Health Foundation of India (PHFI) on antibiotic prescription rates-
- India one of top users of antibiotics in world
- private sector clocked high levels of antibiotic prescription rates (412 per 1,000 persons per year).
- highest rate was seen among children aged 0–4 years (636 per 1,000 persons) and the lowest in the age group 10–19 years (280 per 1,000 persons)
- Per-capita antibiotic consumption in the retail sector has increased by around 22% in five years from 2012 to 2016
Intro/conclusion for ‘ Antibiotic resistance’?
- discovery of antibiotics less than a century ago was a turning point in public health
- Although antibiotic resistance develops naturally with normal bacterial mutation, humans are speeding it up by using antibiotics improperly.
- According to a research, now, 2 million people a year in the US develop antibiotic-resistant infections, and 23,000 of them die of those infections.
- Medical experts are afraid that we’re one step away from deadly, untreatable infections, since the mcr-1 E.coli is resistant to that last-resort antibiotic Colistin.
- Already, infections like tuberculosis, gonorrhea, and pneumonia are becoming harder to treat with typical antibiotics.
- A comprehensive estimate of the global impact of antimicrobial resistance (AMR), covering 204 countries and territories and published in The Lancet, has found that 1.27 million people died in 2019 as a direct result of AMR, which is now a leading cause of death worldwide, higher than HIV/AIDS or malaria.
- Resistance to two classes of antibiotics often considered the first line of defence against severe infections – fluoroquinolones and beta-lactam antibiotics – accounted for more than 70% of deaths caused by AMR.
Antimicrobial reisstance: facts and figures?
Global Research on Antimicrobial Resistance (GRAM) report, published in Lancet
● 1.27 million people died in 2019 as a direct result of AMR.
● AMR is now a leading cause of death worldwide, higher than HIV/AIDS or malaria.
● Besides, another 49.5 lakh deaths were indirectly caused by AMR
● Of the 23 pathogens studied, drug resistance in six (E coli, S aureus, K pneumoniae, S pneumoniae, A baumannii, and P aeruginosa) led directly to 9.29 lakh deaths and was associated with 3.57 million.
● One pathogen-drug combination – methicillin-resistant S aureus, or MRSA – directly caused more than 1 lakh deaths.
● Resistance to two classes of antibiotics often considered the first line of defence against severe infections – fluoroquinolones and beta-lactam antibiotics – accounted for more than 70% of deaths caused by AMR.
Antimicrobial resistance: initiatives by GoI?
- Currently, there are no global standards for antibiotic discharge limits in the environment from pharmaceutical industries. India is the only country to have issued the Draft Environment Protection Amendment Rules in January 2020 to limit the amount of antibiotic residue permitted in wastewater released by drug factories. If notified, it will shift the paradigm from a focus on the quality of medicine to the impact, manufacturing has on workers and the environment.
- National Action Plan on Antimicrobial Resistance 2017-21:
- obj
- improve awareness and understanding
- strengthen surveillance
- reduce incidence of infection through effective prevention
- optimize usage of antimicrobial agents in health, animals and food
- promote investments for AMR activities, Rsearch and innovations
- focusing on One Health approach
- In the line with NAP-AMR three states have launched their state action plan
- Kerala has launched KARSAP
- Madhya Pradesh has launched MP-SAPCAR
- Delhi has launched SAPCARD
- obj
- AMR Surveillance Network: ICMR has established AMR surveillance and research network (AMRSN) in 2013, to generate evidence and capture trends and patterns of drug resistant infections in the country.
- National programme on AMR containment was launched during 12th FYP in 2012-17. Under this programme, AMR Surveillance Network has been strengthened by establishing labs in State Medical College.
- ICMR has initiated antibiotic stewardship program (AMSP) on a pilot project basis in 20 tertiary care hospitals across India to control misuse and overuse of antibiotics in hospital wards and ICUs.
- On the recommendations of ICMR, DCGI has banned 40 fixed dose combinations (FDCs) which were found inappropriate.
- ICMR has developed evidence based treatment guidelines for treatment of ten syndromes of infections. It aims to rationalize the usage of antibiotics on Essential Medicines Formulary (EMF) and to establish consistency in the treatment of various infectious conditions.
Antimicrobial resistance: initiatives by international orgs?
- Global leaders, including India, adopted a political declaration in 2016 at 71st UNGA which calls for a collaborative,global response to the threat of AMR
- In 2019 a new indicator was added to the SDG framework specifically addressing resistance (Indicator 3.d.2: Reduce the percentage of bloodstream infections due to selected antimicrobial resistant organisms)
- Global Antimicrobial Resistance Surveillance System (GLASS) was set up under WHO
Banning e-cigarettes?
- Bill passed in Parliament 2. production, manufacture, import, export, transport, sale, distribution, storage, and advertisement of e-cigarettes and similar devices as cognizable offences. 3. These include all forms of Electronic Nicotine Delivery Systems, Heat Not Burn Products, e-Hookah and the like devices. 4. WHO has also urged member countries to take appropriate steps
ROTAVAC5D: what is it?
- New rotavirus vaccine launched 2. by BharatBiotech
Rotavirus: 1)significance? 2) feature 3) difference frm normal diarrhoea?
1.1) leading cause of severe diarrhoea and death among children less than five years of age. 1.2) responsible for around 10% of total child mortality every year. 2.1) It is a genus of double-stranded RNA virus in the Reoviridae family 2.2) transmitted by the faecal-oral route, via contact with contaminated hands, surfaces and objects, and possibly by the respiratory route. Viral diarrhea is highly contagious. 3) Other diarrhoea can be prevented through general measures like good hygiene bt rotavirus needs vaccine
‘Eat right movement’ campaign: 1. by? 2. aim? 3. about?
- by FSSAI 2. aims to cut down salt/sugar and oil consumption by 30% in three years 3.1) regulatory measures under three major pillars: Eat Safe, Eat Health and Eat Sustainably 3.2) FSSAI has prescribed a limit for Total Polar Compounds (TPC) at 25% in cooking oil to avoid the harmful effects of reused cooking oil
Online sale of medicines: 1. legal standing? 2. what all has happened on it?
- Ministry of Health, Central Drugs Standard Control Organisation and an expert committee appointed by the drug consultative committee have already concluded that the online sale of medicines is in contravention of the provisions of Drugs and Cosmetics Act, 1940 and the other allied laws. 2. Delhi HC in December 2018 had ordered the ban on sale of illegal or unlicensed online sale of medicines till the government drafts rules to regulate e-pharmacies. E-pharmacies told the Court that they do not require a license for online sale of drugs and prescription medicines as they do not sell them, instead they are only delivering the medications akin to food-delivery app Swiggy. Ministry of health and family welfare, in September 2018, issued a draft notification on the sale of drugs by E-Pharmacies
Highlights of draft notification on sale of drugs by e-commerce companies?
- All the e-pharmacies have to be registered compulsorily with the CDSO 2. Psychotropic substances, habit-forming medicines like cough syrup and sleeping pills, schedule x drugs will not be sold online. 3. Apart from registration, the e pharmacies have to obtain a license from the State government to sell the medicines online. 4. e-pharmacy registration holder will have to comply with provisions of Information Technology Act, 2000 5. The details of patient shall be kept confidential and shall not be disclosed to any person other than the central government or the state government concerned, as the case may be. 6. The supply of any drug shall be made against a cash or credit memo generated through the e-pharmacy portal and such memos shall be maintained by the e-pharmacy registration holder as record. 7. Both state and central drug authorities will be monitoring the data of sales and transactions of e pharmacies. Any violation of rules the registration of e-pharmacies will be suspended, and it can be cancelled too. 8. The premises from which e-pharmacy is operated regular inspections will be conducted every two years by the central licencing authority.
T/F: india has the highest burden of all malaria cases.
F Nigeria (24%)
What is Kawasaki disease?
- It affects children, typically <5yrs.
- Its symptoms include red eyes, rashes, and a swollen tongue with reddened lips — often termed strawberry tongue — and an inflamed blood vessel system all over the body.
- There is constant high fever for at least five days.
- The disease also affects coronary functions in the heart.
- What causes Kawasaki disease is not yet known. “What we do know is that it is an immunological reaction to an infection or a virus. A child’s immunity system responds to a particular infection and develops these symptoms
- in rare cases that children with Covid-19 have shown symptoms similar to those of Kawasaki disease, 2-3 weeks after getting infected with coronavirus. In Covid-19 cases, even adolescents are presenting these symptoms.
INdian Education Resilience amid COVID?
- government has initiated the YUKTI web portal, the Aarogya Setu app has been made available for free and the National Foundational Literacy and Numeracy Mission aims to boost literacy.
- National Curriculum and Pedagogical Framework and the Bharat Padhe online campaign are bringing knowledge to the grass roots.
- Prime Minister’s e-Vidya scheme synergises and strengthens several distance-education projects — digital, online, and mass media.
- Benefitting 25-crore school children, it focuses on developing permanent assets for quality education for generations to come.
- A dedicated channel for every class will ensure easy, customised lessons and study material.
- Importantly, it focuses on equity in education.
- This endeavour also individualises the teaching-learning experience to a considerable extent.
- For the differently-abled, this scheme provides bespoke materials under the Digitally Accessible Information System (DAISY). Webinars, podcasts, and online classes enrich the learning experience.
- government has tried to address the equally important issue of psychological health with Manodarpan, a programme that covers both parents and students at a time when unprecedented challenges and stress have raised mental health issues.
- Private Endeavours like University Social Responsibility (USR), under which free online open educational resources in English, Sanskrit, Hindi, Arabic, Chinese, French, German, Italian, Japanese, Korean, Persian, Russian
- EnglishPro, a free mobile app, is ready for launch to help those around the SSC/Class X level in improving their English pronunciation in the Bharatiya way
TULIP programme?
- TULIP – Urban Learning Internship Program for providing opportunities to fresh Graduates in all ULBs & Smart Cities
- pursuant to the Budget 2020-21 announcement under the theme ‘Aspirational India’.
- It would help enhance the value-to-market of India’s graduates and help create a potential talent pool in diverse fields like urban planning, transport engineering, environment, municipal finance etc.
- It will lead to infusion of fresh ideas and energy with engagement of youth in co-creation of solutions for solving India’s urban challenges.
- This launch is also an important stepping stone for fulfilment of MHRD and AICTE’s goal of 1 crore successful internships by the year 2025.
SWADES initiative?
- part of the Vande Bharat Mission, fr the Indian citizens returning frm abroad, especially in the wake of COVID
- It is a joint initiative of the Ministry of Skill Development & Entrepreneurship, the Ministry of Civil Aviation and the Ministry of External Affairs.
- The National Skill Development Corporation (NSDC)is supporting the implementation of the project.
- It aims to create a database of qualified citizens based on their skill sets and experience to tap into and fulfil demand of Indian and foreign companies.
- The collected information will be shared with the companies for suitable placement opportunities in the country.
- The returning citizens are required to fill up an online SWADES Skills Card.
- The card will facilitate a strategic framework to provide the returning citizens with suitable employment opportunities through discussions with key stakeholders including state governments, industry associations and employers.
Ebola?
- Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever, is a severe, often fatal illness in humans.
- origins:
- named after river in Congo, where it was first recognised in 1976
- cases found in Sudan, DRC, Republic of Congo, Gabon and Liberia, Guinea, Sierra Leone, Nigeria, Mali etc. secondary infections also in USA, Spain
- Transmission: The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission, via
- direct contact with blood and secretions of infected persons
- contact with contaminated objects like needles
- eating contaminated meat
- The average EVD case fatality rate is around 50%. Case fatality rates have varied from 25% to 90% in past outbreaks.
- Prevention: Community engagement is key to successfully controlling outbreaks. Good outbreak control relies on case management, surveillance and contact tracing, a good laboratory service and social mobilisation.
- Treatment: Early supportive care with rehydration, symptomatic treatment improves survival. There is yet no licensed treatment proven to neutralise the virus but a range of blood, immunological and drug therapies are under development.
- Vaccine: rVSV-ZEBOV vaccine is being used in the ongoing 2018-2019 Ebola outbreak in DRC.
Why Indian institutions do not fare well in International rankings like QS World university rankings? vs NIRF?
In international rankings, Indian institutions struggle on the “internationalisation” parameter in global rankings. It is due to the high weightage given to the perception which is a subjective parameter.
Whereas, in NIRF, 90% of the parameters are completely objective and fact-based, while only 10% is based on the subjective parameter of perception by academic peers and employers.
Case study of successful vaccination communication from remote region in MH: Melghat?
Vaccination in Melghat, nestled within a forest, a core tiger reserve and home to the Korku tribals, offers rich insights into behaviour, culture and the relationship between them
- A mode of communication that belonged to the people: shooting episodes of a serial we called Corona haarativa, Melghat jitauva (Corona will lose, Melghat will win), which was broadcast on YouTube. The tribal residents of Melghat acted in the serial, it was in their language, it had them asking questions and answering those questions.
- tailored vaccination camps around their work schedules. Villagers cannot sit at home all day long as most of them work for MGNREGA or in their fields.
- moved vaccination centres to open spaces in villages. That way, people could see others taking the vaccine.
- clapped for the first set of vaccinations and made sure the camp felt like a festival in the village, sometimes using music or our videos.
- set up intermittent goals. Which village can get itself 100 per cent vaccinated first? Reaward and challenge system. challenge to the sarpanches: Getting their gram panchayat bodies 100 per cent vaccinated because people would listen only to leadership that practises what it preaches.
- Post vaccination enquiry some days to see if they are doing good. People need belief that they are being cared for
The 6 important Guiding principles learnt frm the success of Swachh Bharat Mission, that can be applied to any large Transformation Scheme?
A-> Align: A goal congruence has to be achieved across the administrative system; continuous engagement with states, 700 DMs (engaged by team SBM-Grameen), 2.5L panchayats; employ workshops and whatsapp grps for officials. PM-CM-DM model in cohesion
B->Believe: A mix of Younger people with less baggage and unique ideas and experienced but driven bureaucrats
C-> Communicate: SBM basically a behaviour change program;Swachgrahis for door-to-door;engaging media and star power to make it glamorous; Keep the buzz alive throughout its life-cycle; recent study by Dalberg found that each rural Indian was reached by SBM messaging abt 3000 times over past 5 yrs.
D-> Democratise: Make everyone a stake holder; communities planned activities and monitoring of progress; Corp, NGOs and civil society too
E-> Evaluate: third party monitoring of progress and evaluation; felicitation of pockets of excellence achieved and their models replicated
F-> Follow Through: NO ‘missionaccomplished’, need to sustain the efforts to not relapse; post delivery follow thorugh to ensure that change becomes norm
Swachh Survekshan league?
conducted in three quarters (April-June, July-September and October-December) with the objective of sustaining the on-ground performance of cities along with monitoring of when it comes to cleanliness.
Swachh Survekshan 2020 is the 5th edition of the annual urban cleanliness survey conducted by the Ministry. first conducted in 2016, which covered 73 cities. The second and third round of the survey in 2017 and 2018 widened the coverage
Findings:
- Cleanest city: Indore for the fourth time in a row.
- Worst: Kolkata
- In cities with pop>10L, Bhopal and rajkot stood second in first and second quarters respectively.
- Among cantonment boards, Tamil Nadu’s St.Thomas Mount Cantt and Delhi Cantt stood 1st in the first and second quarters respectively.
Concept of social mobility? significance?
- concept of social mobility is much broader than just looking at income inequality. It encompasses several concerns such as:
- Intragenerational mobility: The ability for an individual to move between socio-economic classes within their own lifetime.
- Intergenerational mobility: The ability for a family group to move up or down the socio-economic ladder across the span of one or more generations.
- Absolute income mobility: The ability for an individual to earn, in real terms, as much as or more than their parents at the same age.
- Absolute educational mobility: The ability for an individual to attain higher education levels than their parents.
- Relative income mobility: How much of an individual’s income is determined by their parents’ income.
- Relative educational mobility: How much of an individual’s educational attainment is determined by their parents’ educational attainment.
- ‘sticky floors’ and ‘sticky ceilings’ in high income countries i.e. stagnation at both the bottom and the top end of the income distribution
- For instance, in Denmark or Finland (which rank highest in social mobility index), if Person A’s parent earns 100% more than Person Z, it is estimated that the impact on Person A’s future income is around 15%, but in the US the impact is far more – about 50%– and in China, the impact is even more – roughly 60%.
- Social mobility levels helps in understanding both the speed(how long it takes for individuals at the bottom of the scale to catch up with those at the top) and the intensity ( how many steps it takes for an individual to move up the ladder in a given period). eg. it would take a whopping 7 generations for someone born in a low-income family in India or China to approach mean income level; in Denmark, it would only take 2 generations.
- Research also shows that countries with high levels of relative social mobility—such as Finland, Norway or Denmark— exhibit lower levels of income inequality.
ASER2018: highlights?
- Indian students, especially those in elementary school (Classes I-VIII), are not learning enough. To cite a metric, only half (50.3%) of all students in Class V can read texts meant for Class II students.
- There seems to have been some improvement in learning levels, especially among students of Class III and Class V, in 2018 compared with those of the previous five years. However, the improvement is not visible at a higher level, for example among students of Class VIII.
- deficit is across government and private schools. Traditionally, students in private schools have fared better than their government school counterparts, but that’s a relative situation. For example, while 40% of Class VIII students in government schools can do simple division, the figure is 54.2% in private schools.
- gradual improvement in some segments and in some states. The reading ability among Class V students in Kerala jumped 10 percentage points in 2018 from that in 2016. In Himachal Pradesh, the growth is nearly 8 percentage points and in Chhattisgarh and Odisha it is around 7 percentage points between 2016 and 2018
- less than a percentage point growth since 2014(30.8%) among students in the 6-14 age group who were in private schools
- Access to elementary (classes I-VIII) schooling is almost universal and the number of children out of schools is below 4%, but there is a quality deficit
- Last year, the World Bank said Indians born today are likely to be just 44% productive as workers, way below their Asian peers.
ASER2019:highlights?
- latest edition focuses on early years, defined globally as age 0-8, is known to be the most important stage of cognitive, motor, social and emotional development in the human life cycle.
- Only 16% of children in Class 1 in 26 surveyed rural districts can read text at the prescribed level, while almost 40% cannot even recognise letters.
- Only 41% of these children could recognise two digit numbers.
- Many Indian parents choose government schools for girls in the age group of 4 to 8 years while they favour private schools for boys.
- At least 25% of school children in the four-eight age group do not have age-appropriate cognitive and numeracy skills, making for a massive learning deficit at a very early stage.
- More than 90% of children in the 4-8 age group are enrolled in some type of educational institution. This proportion increases with age, from 91.3% of all 4-year-olds to 99.5% of all 8-year-olds
- Children from less advantaged homes are disproportionately affected. Although almost half of all 4-year-olds and more than a quarter of all 5-year-olds are enrolled in anganwadis, these children have far lower levels of cognitive skill and foundational ability than their counterparts in private LKG/UKG classes.
- Overall, 41.7% of children in class I are of the RTE-mandated age.
- Children’s skills and abilities improve in each subsequent class. As per the report, “children’s ability to read standard I level text improves from 16.2% of children in standard I to 50.8% children in standard III. This means that half of all children in standard III are already at least two years behind where the curriculum expects them to be
- Among the pre-primary section, children with mothers who completed eight or fewer years of schooling are more likely to be attending anganwadis or government pre-primary classes. Whereas their peers whose mothers studied beyond the elementary stage are more likely to be enrolled in private LKG/UKG classes.
ASER2019: measures suggested?
- Focus on cognitive skills rather than subject learning in the early years can make a big difference to basic literacy and numeracy abilities.
- Children’s performance on tasks requiring cognitive skills is strongly related to their ability to do early language and numeracy tasks.
- focussing on play-based activities that build memory, reasoning and problem-solving abilities is more productive than an early focus on content knowledge.
- Global research shows that 90% of brain growth occurs by age 5
- entire age band from 4 to 8 needs to be seen as a continuum, and curriculum progression across grades and schooling stages designed accordingly
- Expand and strengthen the existing network of anganwadi centres.
ASER Rport: general features? parameters of assessment in 2019 report?
- an annual survey that aims to provide reliable estimates of children’s enrolment and basic learning levels
- conducted every year since 2005 in all rural districts of India.
- largest citizen-led survey in India.
- only annual source of information on children’s learning outcomes available in India today.
- Unlike most other large-scale learning assessments, ASER is a household-based rather than school-based survey. This design enables all children to be included – those who have never been to school or have dropped out, as well as those who are in government schools, private schools, religious schools or anywhere else.
- Covers >25 districts and >1500 villages and > 35000 children
- All tasks done one-on-one with children in their homes.
- Cognitive: eg. sort by color? spatial awareness? order by size
- early language: eg. describe picture
- early numeracy: eg. counting objects
- social and emotional: eg. identify emotions and regulate them
‘Rare diseases’?
- A rare disease, also referred to as an orphan disease, is any disease that affects a small percentage of the population.
- no universally accepted definition of rare diseases. In the US, for instance, a rare disease is defined as a condition that affects fewer than 200,000 people.The same definition is used by the National Organisation for Rare Disorders (NORD).
- Most rare diseases are genetic
- Rare diseases are characterised by a wide diversity of symptoms and signs that vary not only from disease to disease but also from patient to patient suffering from the same disease.
- Rare diseases pose a significant challenge to health care systems because
- the difficulty in collecting epidemiological data,
- which in turn impedes the process of arriving at a disease burden,
- calculating cost estimations and
- making correct and timely diagnoses
- Many cases of rare diseases may be serious, chronic and life-threatening
- As per the 2017 report, over 50 per cent of new cases are reported in children and these diseases are responsible for 35 per cent of deaths in those below the age of one
- pharma companies are less inclined to invest in R&D fr a rare disease