Social dominance models Flashcards
Albonetti and Farabollini 1994
Social defeat is a potent stressor and repeated defeat is a form of chronic stress which is associated with a decrease in aggressive behaviour
Koolhaas et al., 1990
Mice: single defeat: gradual but long lasting increase in immobility in FST, reversed by clomipramine
Kudryatseva et al., 1991
Mice: repeated defeat- increased immobility in FST, reversed by imipramine
Keeney and Hogg 1999
Repeated defeat of subordinate mice= reduced growth, increased core temperature and circulating corticosterone levels= increased stress
Willner et al., 1995
Rats: defeat of dominant rates by a more aggressive strain= loss of dominant status which is restored by chronic clomipramine
Price 1972
There are parallels between depressive illness and submissive behaviour/defeated animals. depressed individuals see themselves as inferior and behave submissively
Hersen et al., 1984
Assertiveness increases social standing and may be used clinically as a psychotherapy for depression and is found to be as effective as TCA treatment
Mitchell and redfern 1992
chronic administration (2 weeks) of either clomipramine or mianserin to the subdominant animal causes an increase in that animal’s rank position at the expense of the level of dominance enjoyed by the dominant group member
What is the attractive feature of the social hierarchy model?
Daily assessment of social structures allows the time course of antidepressant induced elevation of social position to be determined.
Joly and Sanger 1991
There is a suggestion that the social competition test is relevant to anxiety rather than depression
Cobain et al., 1994
Acute treatment of resident rats with antidepressant drugs reduces aggression.
Chronic treatment of resident rats increases aggressive behaviour, including ECS
File and Tucker, 1986
Aggression is the only type of rodent social behaviour consistently increased following chronic treatment with antidepressants
Does the resident intruder test have high or low predictive validity?
High
Mitchell 2005
Face validity is reduced by the fact the test involves normal unmalipulated animals. non-depressed people do not respond to antidepressants
Mitchell and Redfern 1997
Daily dyadic encounters can be used to compare the rate of onset of antidepressant induced elevation in aggression
Mitchell and Redfern 1998
single dose venlafaxine decreases depression and increases flight behaviour.
increase in aggression between days 7 and 14.
Fluoxetine, Venlafaxine, and Paroxetine are all equipotent in terms of behaviour change but show a marked difference in the time course over which chronic treatment increases aggression
