Behavioural phenotypes with contruct validity

Question 1

What are the 3 models with construct validity?

Answer 1

Latent inhibition
5-choice sereal reaction time task
Social behaviour

Question 2

Lubow 1989

Answer 2

If a subject is repeatedly exposed to prospective conditioned stimulus without reinforcement then subjects fail to associate the conditioned stimulus with the unconditioned stimulus and so fail to evoke the conditioned response

Question 3

Gray et al., 1995

Answer 3

Schizophrenics exhibit impaired cognitive gating and therefore more easily learn that an unimportant conditioned stimulus is now important. LI-deficits are considered an animal model for related symptoms of schizophrenia

Question 4

Koch and Fendt 2005

Answer 4

Schizophrenia paper

Question 5

What symtpoms does social behaviour allow us to model in schizophrenia?

Answer 5

The negative symptoms

Question 6

What are included in the negative symptoms of schizophrenia?

Answer 6

social withdrawal and retreat