Sn1,Sn2,E1,E2 Flashcards
What happen in Sn1 and E1 first?
The leaving group leaving the subtrate first to form carboncation
Sn1/E1 rules
Weak nucleophile
Electrophile stability: 3,2
Nuc strong in protic solvent
Good leaving group :I>Br >CL >F
What rule that both E2&E1 have to follow
Zits eve rule
What’s ZAITSEV RULE?
The strong/weak base will attach to hydrogen of adjacent carbon has fewest hydrogen
Form most substituents at double bond
What the rate of Sn1?
Rate=k [ nucleophile] [ electrophile]
What is the rate of Sn1?
Rate= k[ electrophile or substrate]
What happened to the X leaving group and H in E2?
They both leave at anticoplanar
For cyclohexane, they have to trans one up and 1 down
What happen to the product of Sn2?
Have to be inverted
E2 rules
Strong base
Electrophile: meth,1,2
Good leaving group:I>br>cl>f
Protic solvent
Sn2 rules
Strong nucleophile
Electrophile 3,2,1
Protic solvent
Good leaving group
Exception rules of E2
Presence of tertbutoxide (co)3CO-, then attach to the hydrogen of carbon has more hydrogen to have product with less substituents at double bond
What base that used Hofmann rule in E2?
Tertbutoxide
LDA
What product is more major if there is cis/trans in E2,E1?
Trans is the major product
Strong nucleophile but with base
CL- H2S. HS-
Br- RSH. RS-
I-
STRONG BASE
Tert butoxide
H:-
