SM_284b: Cancer Survivorship

Question 1

Describe the most common cancers in the survivorship population

Answer 1

Most common cancers in the survivorship population

• Prostate
• Thyroid
• Testis
• Melanoma of skin
• Breast (female)
• Hodgkin lymphoma

Question 2

Cancer survivors commonly have ____ and ____

Answer 2

Cancer survivors commonly have chronic health conditions and late mortality

Question 3

Cardiac effects associated with anti-cancer drugs are ___, ___, ___, and ___

Answer 3

Cardiac effects associated with anti-cancer drugs are myocardial depression, ischemia, hypotension, hypertension, and other toxic effects

Question 4

Anthracyclines may cause ____

Answer 4

Anthracyclines may cause cardiac toxicity

(Doxarubicin, epirubicin, donarubicin, idarubicin, mitoxantrone)

Question 5

Trastuzumab is a ___ that may cause ___

Answer 5

Trastuzumab is a monoclonal antibody to the Her2 neu ligand that may cause cardiac toxicity

• Cardiac tissue has Her2 neu receptors

Question 6

Antiangiogenic agents may cause ____ and ____

Answer 6

Antiangiogenic agents may cause HTN based on dose / duration and CHF and coronary syndrome due to vasoconstriction

• Bevacizumab, sunitinib, sorafenib, and pazopanib

Question 7

Platinum agents confer increased risk of ___

Answer 7

Platinum agents confer increased risk of premature atherosclerosis secondary to endothelial damage

• Cisplatin, carboplatin, and oxaliplatin

Question 8

Chemotherapy agents may cause ___ that are not reversible

Answer 8

Chemotherapy agents may cause pulmonary effects that are not reversible

• Fibrosis due to chemo or radiation
• Bleomycin (testicular, Hodgkin’s)
• Mediastinal radiation (Hodgkin’s, breast, lung)

Question 9

Chemotherapy agents may cause ___

Answer 9

Chemotherapy agents may cause peripheral neuropathy

• Platinum agents most common
• Reversible or irreversible
• Hearing loss from cisplatin
• Therapy: gabapentin, venlafaxine

Question 10

Late effects of cancer treatment affect ___, ___, and ___

Answer 10

Late effects of cancer treatment affect heart, lungs, and nerves

• Cardiac
• Pulmonary fibrosis
• Peripheral neuropathy

Question 11

Describe psychosocial challenges of cancer survivorship

Answer 11

Psychosocial challenges of cancer survivorship

• Psychological: depression, anxiety, isolation, uncertainty, altered body image
• Social: changes in interpersonal relationships, jobs, school, financial burden
• Spiritual: sense of purpose or meaning, appreciation of life

Question 12

Describe survivorship care plans

Answer 12

Survivorship care plans

• Personalized treatment summary
• Info on late and long-term effects
• Info on signs of recurrence
• Guidelines for follow-up care
• Identification of providers
• Recommendations for healthy living
• Identification of supportive care resources