SM 218a - Cartilage Histology

Question 1

Which cells produce the matrix that makes up cartilage?

Answer 1

Chondrocytes

Question 2

What is the role of hyaluronic acid in the extracellular matrix?

Answer 2

Hyaluronic acid = larges glycosaminoglycan in the matrix

• Forms complexes with negative charges
• Binds with water to give the matrix viscosity, strength, and flexibility

Question 3

Where i shyaline cartilage found?

Answer 3

• Respiratory tube
• Costal cartilage
• Cartilage in the nose

Question 4

Which number labels a lacunar space?

Answer 4

1

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002

Question 5

What structure does #4 indicate?

Answer 5

Interterritorial matrix

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002

Question 6

What structure does #3 indicate?

Answer 6

Territorial matrix

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002

Question 7

What are the 3 types of cartilage?

Describe the composition of each

Answer 7

• Hyaline cartilage
  
  • Collagen - Type II is the most abundant
  • Proteoglycans
  • Chondrocytes
• Elastic cartilage
  
  • Has elastic fibers within the matrix
• Fibrocartilage
  
  • Has Type I collagen fibers running through the matrix

Question 8

Which of the followign would be present in the meniscus but not in the trachea?

1. Bands of Type I collagen
2. Elastic fivers
3. Type II collagen
4. Hyaluronic acid
5. Water

Answer 8

A. Bands of Type I collagen

• Meniscus
  
  • Fibrocartilage; contains bands of Type I collagen
• Trachea
  
  • Hyaline cartilage; no type I collagen or elastic fibers
• All cartilage
  
  • ​Type II collagen, hyaluronic acid, and water

Question 9

Where is fibrocartilage found?

Answer 9

• Intervertebral discs
• Meniscus

Question 10

What kind of cartilage is this?

(Two different stains shown)

Answer 10

Elastic cartilage

(Elastic stains show elastic fibers in black)

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00111

Question 11

What kind of cartilage is this?

Answer 11

Hyaline cartilage

Question 12

Which type of cartilage is most prevalent in the human body?

Answer 12

Hyaline

Question 13

What is the difference between territorial and Interterritorial matrix?

Answer 13

• Territorial
  
  • Newer
  • Found near chondrocytes
  • Darker staining
• Interterritorial
  
  • More mature
  • Found further away from chondrocytes
  • Lighter staining

Question 14

Where is elastic cartilage found?

Answer 14

• Epiglottis
• External ear cartilage

Question 15

What structure does #2 indicate?

Answer 15

Chondrocyte

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002

Question 16

Chondrocytes are found in _____ spaces

Answer 16

Chondrocytes are found in lacunar spaces

Question 17

Which kind of cartilage has a “herringbone pattern?”

Answer 17

Fibrocartilage

Found in intervertebral disks and the meniscus

Question 18

Describe the composition of cartilage

Answer 18

Cartilage = Chondrocytes + Surrounding matrix

• Matrix
  
  • ​Water + Collagen + Proteoglycans + Glycosaminoglycans
  • Collagen is mostly type II
  • Most importatn glycosaminoglycan is
• *hyaluronic acid**

Question 19

What are the functions of cartilage?

Answer 19

• Support the body
• Articulate joints
• Provide attachment sites for muscles
• Improve flexibility
• Act as a scaffold for bone development

Question 20

What type of cartilage comprises the meniscus?

Answer 20

Fibrocartilage

Question 21

What type of tissue is cartilage?

Answer 21

Connective tissue

Question 22

What kind of cartilage is this?

Answer 22

Fibrocartilage

• Alternating layers in a herringbone pattern
• Collagen runs though the layers giving fibrocartilage resistance to compressive forces (ex: in intervertebral discs)

http://virtualslides.med.umich.edu/Histology/Basic%20Tissues/Cartilage%20and%20Bone/045_HISTO_40X.svs/view.apml?cwidth=817&cheight=1021&chost=virtualslides.med.umich.edu&csis=1&X=0&Y=0&zoom=4.09417768499188&listview=1

Question 23

What structure does #5 indicate?

Answer 23

Isogenous groups

https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002

Question 24

Collagen running through fibrocartilage in layers gives the intervertebral disk resistance to __________ forces

Answer 24

Collagen running through fibrocartilage in layers gives the intervertebral disk resistance to compressive forces