Slide 3 Flashcards
What are the main inputs of the basal ganglia and the cerebellum?
- cortical motor areas
- brainstem
- sensory areas
Output of basal ganglia and cerebellum
- interact with different levels of cortical motor circuit
- through thalamus to cortex
- directly on brainstem
What is the basal ganglia?
- collection of interconnected nuclei
- part of subcortical loop
- receives cortical input
- sends output back via thalamus
Basal ganglia is involved in modulating…
- movement
- learning
- cognitive functions
What is Parkinson’s disease caused by?
- loss of DA neurons
- in the substantia nigra
What does cerebellum mean in latin?
little brain
What percent of the brain’s mass does the cerebellum make up
10%
What percent of the brain’s neurons does the cerebellum contain?
50%
Structure of cerebellum
- 2 hemispheres
- 3 pairs of deep nuclei
How is the cerebellum organized?
- topographically
- highly regular cellular organization
What are the three layers of the cerebellum?
- molecular layer
- purkinje cell layer
- granular layer
Describe the molecular layer of the cerebellum
- parallel fibers
- inputs
Describe the purkinje cell layer of the cerebellum
- output neurons
- GABA
Describe the granular layer of the cerebellum
-input neurons
How many input neurons does the granular layer of the cerebellum contain?
60-80 billion
Where does the cerebellum receive input from?
- primary motor cortex
- secondary motor cortex
- brainstem motor nuclei