Sleep Disorders

Question 1

Drugs used for Restless Leg Syndrome

Answer 1

Gabapentin
Pramiprexole (Mirapex)
Ropinirole (Requip)
Rotigotine (Neupro) patch - daily

Question 2

Drug class used in Narcolepsy

Answer 2

Stimulants (modafinil, armodafinil, methylphenidate, etc)

Question 3

What drug class requires a 14-day washout period in someone who has been using phenelzine?

Answer 3

TCAs (Doxepin)

*Phenelzine is a MAOI

Question 4

Date rape drug

Answer 4

Sodium oxybate

• if used as C-I (illicit drug)
• C-III used for Narcolepsy
• REMS program

Question 5

Counseling pearl for pramiprexole and ropinirole

Answer 5

Take 1-3 hours before bedtime

Question 6

Drug class of choice used for RLS

Answer 6

Dopamine agonists

*also used in Parkinson’s

Question 7

What drugs increase GABA leading to an inhibitory effect by binding to benzodiazepine receptor-subtypes specific for sedation?

Answer 7

Eszopiclone
Zolpidem
Zaleplon

Question 8

Zolpidem formulations

Answer 8

Oral spray & IR, CR, and SL tablet

Question 9

Medical Terminology for unusual actions while sleeping, of which the patient may not be aware of is called?

Associated with what drugs?

Answer 9

Parasomnias

Drugs: Eszopiclone, Zaleplon, & Zolpidem

Question 10

Beers Criteria drug classes

Answer 10

Benzodiazepines (triazolam)
Non-benzos (zolpidem)
1st- gen antihistamines (benadry)

Question 11

Need Help Falling Asleep?

Answer 11

Eszopiclone
Zaleplon
Zolpidem
Ramelteon

Question 12

Need Help Staying Asleep?

Answer 12

Eszopiclone
Zolpidem
Suvorexant
Doxepin

Question 13

Need Help Falling & Staying Asleep?

Answer 13

Eszopiclone

Zolpidem

Question 14

Name the hypnotics & antidepressants drugs.

Answer 14

“CIV”
Zolpidem (Ambien)
Zaleplon (Sonata)
Eszopiclone (Lunesta)

Suvorexant (Belsomra) - orexin-receptor antag

Ramelteon (Rozerem) - melatonin-receptor agonist

Doxepin ER (Silenor) - antidepressant

Question 15

Diagnosis for Insomnia

Answer 15

Having symptoms at least 3x/week for > 3 months

Sx: falling asleep, staying asleep, awakening after sleep onset

Question 16

Drugs that can worsen insomnia

Answer 16

Alcohol
Stimulants
Bupropion 
Caffeine 
PSE
Diuretics
Fluoxetine 
Steroids
Varencline

Question 17

Natural Products for Sleep

Answer 17

Chamomile Tea
Valerian
Melatonin

Question 18

Drug used for non-24 hour sleep-wake disorder

Answer 18

tasimelteon (Hetlioz)

Question 19

Horizant generic

Answer 19

gabapentin enacarbil