Sleep and Synaptic Homeostasis

Question 1

Why do we sleep?

Answer 1

Lecture 18, slide 4-8

Question 2

What are the two theories on why we sleep?

Answer 2

• active system consolidation theory

- synaptic homeostasis hypothesis

Question 3

What type of brain activity is detected in REM vs nonREM sleep?

Answer 3

Lecture 18, slide 9-10

Question 4

What is the Active System Reconsolidation Theory of sleep?

Answer 4

Lecture 18, slide 12-13

Question 5

What evidence is there to support the Active System Reconsolidation Theory of sleep?

Answer 5

Lecture 18, slide 14-18

Question 6

What is the Synaptic Homeostasis Hypothesis of sleep?

Answer 6

Lecture 18, slide 19-28

Question 7

How did Vyazovskiy’s study suggest that synapses get stronger during wake, and weaker during sleep?

Answer 7

Lecture 18, slide 31-36

-molecular approach to study the effect of the sleep/wake cycle on synaptic plasticity

Question 8

How did Vyazovskiy’s study suggest that slow-wave activity may actively contribute to the weakening of synaptic connections during sleep?

Answer 8

Lecture 18, slide 37-47

-slow wave decline correlated with LFP decline

Question 9

How did Vyazovskiy’s study suggest that downscaling, during slow-wave activity, may be through an LTD-like/depotentiation mechanism?

Answer 9

Lecture 18, slide 48-52

-it’s harder to induce LTP after wake than after sleep

Question 10

What can we conclude from Vyazovskiy’s study?

Answer 10

Lecture 18, slide 53

Question 11

What implications does the Synaptic Homeostasis Hypothesis of sleep have for memory?

Answer 11

Lecture 18, slide 55-56

Question 12

How may the two theories for why we sleep coexist?

Answer 12

Lecture 18, slide 57-58

Question 13

Evaluate GluA1 dependent memory.

Answer 13

Lecture 18, slide 60-62